\nDiversitatea genetic\u0103 a \u0163\u0103rii \u015fi \u201esupercentenarii\u201d s\u0103i ar putea explica de ce unii oameni tr\u0103iesc peste 110 ani, oferind indicii despre imunitate \u015fi rezilien\u0163\u0103.<\/p>\n
\nOamenii de \u015ftiin\u0163\u0103 se orienteaz\u0103 tot mai mult c\u0103tre Brazilia \u00een c\u0103utarea explica\u0163iilor biologice ale longevit\u0103\u0163ii umane extreme, potrivit SciTechDaily. Cercet\u0103ri recente sugereaz\u0103 c\u0103 diversitatea genetic\u0103 unic\u0103 a \u0163\u0103rii ar putea oferi indicii esen\u0163iale despre motivul pentru care unii oameni tr\u0103iesc peste 110 ani.<\/p>\n
\nUn articol publicat recent \u00een Genomic Psychiatry de cercet\u0103tori de la Universitatea din S\u00e3o Paulo, sus\u0163ine c\u0103 Brazilia este o resurs\u0103 insuficient explorat\u0103 \u00een \u015ftiin\u0163a longevit\u0103\u0163ii. Autorii arat\u0103 c\u0103 decenii de amestec popula\u0163ional au creat tipare genetice rareori reprezentate \u00een bazele de date globale.<\/p>\n
\nA tr\u0103i peste 110 ani r\u0103m\u00e2ne unul dintre cele mai enigmatice fenomene biologice. Majoritatea studiilor despre longevitate se concentreaz\u0103 pe popula\u0163ii genetic omogene, ceea ce limiteaz\u0103 descoperirea unor tr\u0103s\u0103turi protective rare. Popula\u0163ia mixt\u0103 a Braziliei ar putea con\u0163ine variante genetice care ajut\u0103 la men\u0163inerea func\u0163iilor celulare \u015fi imunitare timp de decenii peste medie.<\/p>\n
\nCercet\u0103torii spun c\u0103 ignorarea acestor popula\u0163ii ar fi putut \u00eencetini progresul \u00een \u00een\u0163elegerea \u00eemb\u0103tr\u00e2nirii extreme.<\/p>\n
\nPeisajul genetic al Braziliei a fost format de secole de mo\u015ftenire indigen\u0103, colonizare european\u0103, migra\u0163ie for\u0163at\u0103 african\u0103 \u015fi imigra\u0163ie global\u0103 ulterioar\u0103. Studii genomice ample au identificat deja milioane de variante genetice necunoscute anterior \u00een popula\u0163ia brazilian\u0103. Multe dintre aceste variante lipsesc din bazele de date interna\u0163ionale utilizate \u00een cercetarea \u00eemb\u0103tr\u00e2nirii.<\/p>\n
\nAceast\u0103 diversitate ofer\u0103 o oportunitate rar\u0103 de a descoperi mecanisme biologice asociate cu rezilien\u0163a \u015fi supravie\u0163uirea pe termen lung.<\/p>\n
\nEchipa de cercetare urm\u0103re\u015fte peste 160 de centenari brazilieni, inclusiv 20 de supercentenari valida\u0163i. Mai mul\u0163i participan\u0163i au r\u0103mas lucizi mental \u015fi func\u0163ional independen\u0163i mult dup\u0103 v\u00e2rsta de 110 ani. \u00cen mod remarcabil, mul\u0163i \u015fi-au petrecut cea mai mare parte a vie\u0163ii cu acces limitat la medicina modern\u0103, suger\u00e2nd o rezilien\u0163\u0103 biologic\u0103 mai degrab\u0103 dec\u00e2t interven\u0163ie medical\u0103.<\/p>\n
\nGrupul include unii dintre cei mai longevivi b\u0103rba\u0163i \u00eenregistra\u0163i vreodat\u0103, o raritate \u00een studiile despre longevitate.<\/p>\n
\nAnalizele biologice arat\u0103 c\u0103 supercentenarii men\u0163in procese eficiente de reparare celular\u0103 \u015fi reglare imunitar\u0103. Sistemele lor imunitare prezint\u0103 adapt\u0103ri, nu un declin uniform. \u00cen timpul pandemiei COVID-19, mai mul\u0163i supercentenari brazilieni au supravie\u0163uit infec\u0163iei f\u0103r\u0103 vaccinuri.<\/p>\n
\nCercet\u0103torii au identificat r\u0103spunsuri puternice de anticorpi, ridic\u00e2nd noi \u00eentreb\u0103ri despre \u00eemb\u0103tr\u00e2nirea imunitar\u0103 \u015fi rezisten\u0163a la boli.<\/p>\n
\nOamenii de \u015ftiin\u0163\u0103 extind acum studiile pentru a include modele celulare \u015fi analize multi-omics (date din ADN, gene active, proteine \u015fi metabolism) ob\u0163inute de la participan\u0163ii brazilieni.<\/p>\n
\nScopul este identificarea tr\u0103s\u0103turilor protective care ar putea contribui la o \u00eemb\u0103tr\u00e2nire mai s\u0103n\u0103toas\u0103 la nivel global.<\/p>\n
\nCercet\u0103torii \u00eendeamn\u0103 consor\u0163iile interna\u0163ionale s\u0103 includ\u0103 popula\u0163ii genetic diverse pentru a evita concluzii p\u0103rtinitoare.<\/p>\n","protected":false},"excerpt":{"rendered":"
Diversitatea genetic\u0103 a \u0163\u0103rii \u015fi \u201esupercentenarii\u201d s\u0103i ar putea explica de ce unii oameni tr\u0103iesc peste 110 ani, oferind indicii despre imunitate \u015fi rezilien\u0163\u0103. Oamenii de \u015ftiin\u0163\u0103 se orienteaz\u0103 tot mai mult c\u0103tre Brazilia \u00een c\u0103utarea explica\u0163iilor biologice ale longevit\u0103\u0163ii umane extreme, potrivit SciTechDaily. Cercet\u0103ri recente sugereaz\u0103 c\u0103 diversitatea genetic\u0103 unic\u0103 a \u0163\u0103rii ar putea […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[17014,16273,6266],"class_list":["post-244163","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-brazilia","tag-cercetatori","tag-oameni"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/244163","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=244163"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/244163\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=244163"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=244163"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=244163"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}