\nCercet\u0103torii au demonstrat c\u0103 un vaccin bazat pe nanoparticule poate preveni mai multe tipuri agresive de cancer la \u015foareci, oferind protec\u0163ie imun\u0103 de durat\u0103 \u015fi bloc\u00e2nd metastazele, scrie SciTechDaily.<\/p>\n
\nDescoperirile, realizate la Universitatea din Amherst, Massachusetts, marcheaz\u0103 un pas important c\u0103tre un vaccin universal \u00eempotriva cancerului, cu poten\u0163ial at\u00e2t preventiv, c\u00e2t \u015fi terapeutic.<\/p>\n
\nVaccinul experimental a prevenit cu succes melanomul, cancerul pancreatic \u015fi cancerul mamar triplu negativ la \u015foareci, men\u0163in\u00e2nd p\u00e2n\u0103 la 88% dintre animale f\u0103r\u0103 tumori, \u00een func\u0163ie de tipul de cancer. Prin activarea simultan\u0103 a mai multor c\u0103i ale sistemului imunitar, formularea a generat r\u0103spunsuri puternice ale celulelor T, care au eliminat tumorile \u015fi au \u00eempiedicat r\u0103sp\u00e2ndirea celulelor canceroase \u00een pl\u0103m\u00e2ni. Formul\u0103rile tradi\u0163ionale de vaccin nu au reu\u015fit performan\u0163e similare, toate animalele din grupurile de control dezvolt\u00e2nd tumori \u00een c\u00e2teva s\u0103pt\u0103m\u00e2ni.<\/p>\n
\nCercet\u0103toarea principal\u0103, Prabhani Atukorale, afirm\u0103 c\u0103 for\u0163a vaccinului const\u0103 \u00een capacitatea lui de a genera memorie imun\u0103 sistemic\u0103, permi\u0163\u00e2nd organismului s\u0103 recunoasc\u0103 \u015fi s\u0103 distrug\u0103 celulele canceroase mult timp dup\u0103 vaccinare. Folosind ulterior un amestec de celule tumorale inactivate, care pune la dispozi\u0163ie o varietate mai larg\u0103 de antigene, vaccinul a reu\u015fit s\u0103 protejeze \u00eempotriva mai multor tipuri de cancer f\u0103r\u0103 a necesita secven\u0163ieri genetice personalizate. Rata de respingere tumoral\u0103 a fost de 88% \u00een cancerul pancreatic, 75% \u00een cancerul mamar \u015fi 69% \u00een melanom.<\/p>\n
\nEchipa a creat un adjuvant complex pe baz\u0103 de nanoparticule lipidice, capabil s\u0103 livreze simultan mai mul\u0163i activatori ai sistemului imunitar \u00eentr-o structur\u0103 stabil\u0103, dep\u0103\u015find una dintre limit\u0103rile majore ale vaccinurilor oncologice. Cercet\u0103torii cred c\u0103 aceast\u0103 tehnologie poate fi adaptat\u0103 at\u00e2t pentru preven\u0163ie, c\u00e2t \u015fi pentru tratament, \u00een special pentru persoanele cu risc crescut. Inova\u0163ia a stat deja la baza lans\u0103rii startup-ului NanoVax Therapeutics, care \u00ee\u015fi propune s\u0103 transforme aceast\u0103 descoperire \u00een solu\u0163ii clinice.<\/p>\n","protected":false},"excerpt":{"rendered":"
Un vaccin pe baz\u0103 de nanoparticule previne multiple tipuri de cancer la \u015foareci, oferind protec\u0163ie de durat\u0103 \u015fi bloc\u00e2nd metastazele, un pas important spre dezvoltarea unui vaccin universal.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[62050,36303,62049],"class_list":["post-242948","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-imunoterapie-cu-nanoparticule","tag-oncologie","tag-vaccin-cancer"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/242948","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=242948"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/242948\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=242948"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=242948"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=242948"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}