\nCercet\u0103torii de la Facultatea de \u015etiin\u0163e Biologice \u015fi Comportamentale a Universit\u0103\u0163ii Queen Mary din Londra au descoperit efecte anti-\u00eemb\u0103tr\u00e2nire surprinz\u0103toare ale unui medicament oncologic de genera\u0163ie nou\u0103, ar\u0103t\u00e2nd c\u0103 inhibitorul TOR rapalink-1 poate extinde semnificativ durata de via\u0163\u0103 a drojdiei de fisiune, conform SciTechDaily.<\/p>\n
\nStudiul, publicat \u00een Communications Biology, sugereaz\u0103 c\u0103 tratamentele concepute pentru cancer pot influen\u0163a \u015fi procesul de \u00eemb\u0103tr\u00e2nire prin c\u0103i metabolice \u00eenc\u0103 neexplorate.<\/p>\n
\nRapalink-1, creat ini\u0163ial ca tratament promi\u0163\u0103tor \u00eempotriva cancerului, s-a dovedit c\u0103 \u00eencetine\u015fte \u00eemb\u0103tr\u00e2nirea drojdiei ac\u0163ion\u00e2nd asupra TORC1, partea din calea TOR care controleaz\u0103 cre\u015fterea celular\u0103.<\/p>\n
\nCercet\u0103torii au constatat c\u0103 medicamentul reduce func\u0163iile de cre\u015ftere celular\u0103, stimul\u00e2nd \u00een acela\u015fi timp longevitatea \u015fi eviden\u0163iind compromisurile mecanice tipice biologiei \u00eemb\u0103tr\u00e2nirii.<\/p>\n
\nUna dintre descoperirile majore ale studiului este rolul nea\u015fteptat al agmatinelor (enzime care transform\u0103 metabolitul agmatin\u0103 \u00een poliamine).<\/p>\n
\nAceste enzime fac parte dintr-un nou \u201ecircuit metabolic de feedback\u201d care regleaz\u0103 activitatea TOR.<\/p>\n
\nC\u00e2nd activitatea agmatinelor a fost perturbat\u0103, celulele s-au multiplicat mai rapid, dar au prezentat semne de \u00eemb\u0103tr\u00e2nire timpurie, subliniind echilibrul fragil dintre cre\u015fterea accelerat\u0103 \u015fi s\u0103n\u0103tatea celular\u0103 pe termen lung.<\/p>\n
\nEchipa a demonstrat, de asemenea, c\u0103 administrarea de metaboli\u0163i precum agmatina sau putrescina prelunge\u015fte durata de via\u0163\u0103 a drojdiei \u00een anumite condi\u0163ii metabolice.<\/p>\n
\nAceasta sugereaz\u0103 c\u0103 at\u00e2t medicamentele, c\u00e2t \u015fi compu\u015fii naturali pot influen\u0163a \u00eemb\u0103tr\u00e2nirea prin aceea\u015fi cale biochimic\u0103.<\/p>\n
\nAutorii avertizeaz\u0103 totu\u015fi c\u0103 suplimentele de agmatin\u0103, deja disponibile pe pia\u0163\u0103, trebuie utilizate cu pruden\u0163\u0103, deoarece efectele benefice apar doar dac\u0103 anumite c\u0103i metabolice sunt intacte, iar agmatina poate contribui uneori la patologii.<\/p>\n
\nPentru c\u0103 mecanismul TOR func\u0163ioneaz\u0103 similar de la drojdie p\u00e2n\u0103 la oameni, aceste descoperiri ar putea influen\u0163a viitoarele strategii privind \u00eemb\u0103tr\u00e2nirea s\u0103n\u0103toas\u0103, tratamentele oncologice \u015fi bolile metabolice.<\/p>\n
\nStudiul \u00eent\u0103re\u015fte leg\u0103tura \u015ftiin\u0163ific\u0103 dintre diet\u0103, microbiom \u015fi longevitate, ar\u0103t\u00e2nd cum circuitele metabolice pot controla \u00eemb\u0103tr\u00e2nirea la nivel celular.<\/p>\n","protected":false},"excerpt":{"rendered":"
Un medicament oncologic, care vizeaz\u0103 calea TOR, a prelungit nea\u015fteptat durata de via\u0163\u0103 a drojdiei printr-un nou mecanism metabolic.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[10796,12923],"class_list":["post-242827","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-imbatranire","tag-tratament"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/242827","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=242827"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/242827\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=242827"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=242827"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=242827"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}