\nStimulii senzoriali, precum atingerea \u015fi mirosul, pot anula efectele dietelor restrictive asupra duratei de via\u0163\u0103. Acestea suprim\u0103 gena cheie a longevit\u0103\u0163ii, numit\u0103 fmo-2. Descoperirea ar putea duce la prelungirea vie\u0163ii f\u0103r\u0103 diete extreme \u015fi chinuitoare, scrie Science Daily.<\/p>\n
\nCercetarea, publicat\u0103 \u00een PNAS, folose\u015fte organismul model C. elegans, un vierme studiat pe scar\u0103 larg\u0103, pentru a investiga modul \u00een care semnalele de mediu \u015fi accesul la hran\u0103 influen\u0163eaz\u0103 longevitatea. C\u00e2nd gena fmo-2 este supraactivat\u0103, viermii devin ciudat de indiferen\u0163i la pericol \u015fi hran\u0103, suger\u00e2nd un compromis \u00eentre durata de via\u0163\u0103 \u015fi comportament.<\/p>\n
\nScott Leiser de la Universitatea din Michigan \u015fi Safa Beydoun au descoperit c\u0103 experien\u0163ele senzoriale precum atingerea pot opri efectele benefice ale dietei restrictive. Pentru a testa aceast\u0103 ipotez\u0103, ei au a\u015fezat viermi pe un strat de bile care imitau senza\u0163ia bacteriei E. coli pe care o \u00eent\u00e2lnesc \u00een mod normal \u00een timpul hr\u0103nirii.<\/p>\n
\nAcest indiciu tactil u\u015for a fost suficient pentru a suprima activitatea genei fmo-2 \u00een intestin \u015fi a redus prelungirea duratei de via\u0163\u0103 produs\u0103 de obicei de restric\u0163ia alimentar\u0103. Experimentele au revelat c\u0103 atingerea activeaz\u0103 un circuit neural care modific\u0103 semnalele din celulele care elibereaz\u0103 dopamin\u0103 \u015fi tiramin\u0103, reduc\u00e2nd beneficiile restric\u0163iilor alimentare asupra longevit\u0103\u0163ii.<\/p>\n
\n\u201eEnzima fmo-2 remodeleaz\u0103 metabolismul \u015fi, ca rezultat, cre\u015fte durata de via\u0163\u0103\u201d, a explicat Leiser.<\/p>\n
\n\u201eF\u0103r\u0103 enzim\u0103, restric\u0163ia alimentar\u0103 nu duce la o durat\u0103 de via\u0163\u0103 mai lung\u0103\u201d.<\/p>\n
\nVestea bun\u0103: \u201eDac\u0103 am putea induce fmo-2 f\u0103r\u0103 a elimina alimentele, am putea activa r\u0103spunsul la stres \u015fi am putea p\u0103c\u0103li creierul s\u0103 v\u0103 fac\u0103 s\u0103 tr\u0103i\u0163i mai mult\u201d.<\/p>\n
\n\u201eCrede\u0163i sau nu, majoritatea ideilor centrale \u015fi tipurilor de metabolism pe care le studiem sunt conservate de la viermi la oameni\u201d, a spus Leiser. At\u00e2t oamenii, c\u00e2t \u015fi viermii elibereaz\u0103 hormoni, inclusiv adrenalin\u0103 sau dopamin\u0103, ca r\u0103spuns la ceea ce simt \u00een jurul lor.<\/p>\n
\nCercet\u0103rile anterioare au ar\u0103tat c\u0103 simplul miros al hranei poate contracara beneficiile restric\u0163iei alimentare pentru supravie\u0163uire.<\/p>\n
\n\u00centr-un studiu separat publicat \u00een Science Advances, echipa a descoperit c\u0103 enzima influen\u0163eaz\u0103 comportamentul \u00een moduri surprinz\u0103toare. Viermii modifica\u0163i genetic pentru a supraexprima fmo-2 au devenit bizari: nu s-au retras din fa\u0163a bacteriilor periculoase \u015fi nu s-au oprit s\u0103 se hr\u0103neasc\u0103, a\u015fa cum ar fi f\u0103cut viermii normali. Practic, au devenit indiferen\u0163i la lumea din jurul lor.<\/p>\n
\n\u201eOrice interven\u0163ie pentru prelungirea vie\u0163ii va avea efecte secundare \u015fi credem c\u0103 unul dintre aceste efecte secundare va fi comportamental\u201d, a spus Leiser.<\/p>\n
\n\u201ePrin \u00een\u0163elegerea acestei c\u0103i, am putea furniza suplimente pentru a compensa unele dintre aceste efecte comportamentale negative\u201d.<\/p>\n
\nLeiser inten\u0163ioneaz\u0103 s\u0103 continue investigarea modului \u00een care creierul, metabolismul, comportamentul \u015fi s\u0103n\u0103tatea interac\u0163ioneaz\u0103, cu scopul de a dezvolta medicamente care vizeaz\u0103 aceste c\u0103i naturale pentru a prelungi via\u0163a f\u0103r\u0103 sacrificiile dietelor extreme.<\/p>\n","protected":false},"excerpt":{"rendered":"
Un vierme mic tocmai a dezv\u0103luit un mare secret despre cum s\u0103 tr\u0103ie\u015fti mai mult. Oamenii de \u015ftiin\u0163\u0103 care studiaz\u0103 \u00eemb\u0103tr\u00e2nirea au f\u0103cut o descoperire surprinz\u0103toare.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[43001,231,23754],"class_list":["post-242234","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-metabolism","tag-viata","tag-vierme"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/242234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=242234"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/242234\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=242234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=242234"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=242234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}