\nCercet\u0103torii de la University of Massachusetts Chan Medical School au dezvoltat nanoparticule lipidice care transport\u0103 doi agen\u0163i imunostimulatori, denumite \u201esuper-adjuvan\u0163i\u201d, care pot fi administrate \u00eempreun\u0103 cu antigene tumorale sau lizat de celule canceroase.<\/p>\n
\nSistemul combin\u0103 agoni\u015fti ai c\u0103ii STING \u015fi ai receptorului TLR4 pentru a promova produc\u0163ia sinergic\u0103 de interferoni de tip I \u015fi alte citokine proinflamatorii \u00een celulele care prezint\u0103 antigenul. Aceste nanoparticule au dimensiuni mici, de aproximativ 30-60 nanometri, ceea ce le permite s\u0103 se dreneze rapid c\u0103tre ganglionii limfatici \u015fi s\u0103 fie absorbite eficient de celulele dendritice.<\/p>\n
\nStudiul, publicat \u00een revista \u015ftiin\u0163ific\u0103 Cell Reports, a testat sistemul pe mai multe modele de tumori agresive la \u015foareci, inclusiv melanom, cancer pancreatic \u015fi cancer mamar triplu negativ.<\/p>\n
\nRezultatele au fost remarcabile. Pentru melanom, 69% dintre \u015foarecii vaccina\u0163i au respins tumorile. \u00cen cazul cancerului pancreatic, 88% dintre \u015foarecii vaccina\u0163i au eliminat tumorile, iar pentru cancerul mamar triplu negativ, 75% dintre \u015foareci au respins provocarea tumoral\u0103.<\/p>\n
\nNanoparticulele au promovat cre\u015fterea celulelor T polifunc\u0163ionale, precum \u015fi a celulelor B, cre\u00e2nd un r\u0103spuns imunitar amplu \u00eempotriva cancerului. To\u0163i \u015foarecii vaccina\u0163i care au supravie\u0163uit provoc\u0103rii ini\u0163iale au r\u0103mas f\u0103r\u0103 tumori \u015fi dup\u0103 o a doua provocare sistemic\u0103 cu celule canceroase.<\/p>\n
\nSistemul a fost testat \u015fi pe celule umane de la trei donatori independen\u0163i, confirm\u00e2nd capacitatea sa de a promova produc\u0163ia semnificativ\u0103 de interferon, ceea ce extinde relevan\u0163a \u015fi poten\u0163ialul de aplicare clinic\u0103 al acestei descoperiri.<\/p>\n
\nCercet\u0103torii au subliniat c\u0103 platforma este modular\u0103 \u015fi personalizabil\u0103, put\u00e2nd fi adaptat\u0103 pentru diferite tipuri de cancer f\u0103r\u0103 a fi necesar\u0103 secven\u0163ierea \u00eentregului genom sau screeningul bioinformatic complex.<\/p>\n
\nDe\u015fi rezultatele sunt promi\u0163\u0103toare, oamenii de \u015ftiin\u0163\u0103 recunosc c\u0103 sunt necesare studii suplimentare pentru evaluarea complet\u0103 a siguran\u0163ei \u015fi eficacit\u0103\u0163ii pe modele animale mai mari \u00eenainte de a trece la studii clinice pe oameni.<\/p>\n
\nStudiul a fost finan\u0163at de Institutul Na\u0163ional al Cancerului, Institutul Na\u0163ional de Imagistic\u0103 Biomedical\u0103 \u015fi Bioinginerie \u015fi Institutul pentru \u015etiin\u0163e Aplicate ale Vie\u0163ii.<\/p>\n","protected":false},"excerpt":{"rendered":"
Oamenii de \u015ftiin\u0163\u0103 americani au creat un sistem inovator de nanoparticule care promoveaz\u0103 r\u0103spunsuri imune puternice \u00eempotriva cancerului, oferind o nou\u0103 speran\u0163\u0103 \u00een tratamentul mai multor tipuri de tumori agresive.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[14610,14930],"class_list":["post-241137","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-cancer","tag-vaccin"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/241137","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=241137"}],"version-history":[{"count":1,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/241137\/revisions"}],"predecessor-version":[{"id":241158,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/241137\/revisions\/241158"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=241137"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=241137"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=241137"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}