{"id":240521,"date":"2025-09-24T08:32:18","date_gmt":"2025-09-24T08:32:18","guid":{"rendered":"https:\/\/bm.dev.synology.me\/?p=240521"},"modified":"2025-09-24T08:32:18","modified_gmt":"2025-09-24T08:32:18","slug":"dragos-damian-terapia-cluj-paracetamol-paraacetil-aminofenol-acetaminofen-n-acetil-p-aminofenol-c8h9no2-oricum-ti-ar-spune-lumea-eu-te-iubesc","status":"publish","type":"post","link":"https:\/\/bm.dev.synology.me\/?p=240521","title":{"rendered":"Drago\u015f Damian, Terapia Cluj: Paracetamol, paraacetil-aminofenol, acetaminofen, N-acetil-p-aminofenol, C8H9NO2. Oricum \u0163i-ar spune lumea, eu te iubesc"},"content":{"rendered":"<p>\n<img loading=\"lazy\" decoding=\"async\" height=\"160\" 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width=\"330\" \/><\/p>\n<p>\n&nbsp;<\/p>\n<p>\n&nbsp;<\/p>\n<p>\nTrei disclaimere scurte la inceput. :<\/p>\n<p>\n&nbsp;<\/p>\n<p>\n1. Nu scriu opinii ca si consilier al nimanui, tot ceea ce public este convingerea si responsabilitatea mea personala.<\/p>\n<p>\n&nbsp;<\/p>\n<p>\n2. Sunt un mare fan Donald Trump, este un patriot, un suveranist, un industrialist. Ne lipseste un lider patriot, suveranist, industrialist, asa cum sunt si Emmanuel Macron, Josef Merz, Donald Tusk sau Viktor Orban, ca sa dam cateva exemple de pe continent;<\/p>\n<p>\n&nbsp;<\/p>\n<p>\n2. Nu fabric paracetamol ca produs finit, nici ca substanta activa dar, pentru cei interesati, iata cateva informatii trivia:<\/p>\n<p>\n&#8211; a fost sintetizat prima oara in urma cu 150 de ani, in SUA, este unul dintre cele mai vechi produse farmaceutice de sinteza cunoscute in istorie;<\/p>\n<p>\n&#8211; China si India fabrica 75% din productia mondiala a substantei active, circa 115 mii tone anual, asta fiind echivalentul a circa 11,5 miliarde de cutii a 20 de tablete, in doza cea mai populara de 500mg, cea pe care o gasim in farmacii;<\/p>\n<p>\n&#8211; in iunie 2020, Emmanuel Macron \u015fi-a anun\u0163at voin\u0163a de a restabili suveranitatea sanitar\u0103 a Fran\u0163ei. Compania Seqens a ales s\u0103 readuc\u0103 o parte din produc\u0163ia sa de paracetamol \u00een Fran\u0163a \u015fi s\u0103 investeasc\u0103 \u00een inova\u0163ie pentru a dezvolta un proces de fabrica\u0163ie care s\u0103 fie at\u00e2t competitiv, c\u00e2t \u015fi prietenos cu mediul.<\/p>\n<p>\n&#8211; in SUA se consuma 25 de miliarde de doze, asta fiind echivalentul a circa 1,2 miliarde de cutii a 20 de tablete;<\/p>\n<p>\n&#8211; in UK se consuma 6.300 tone de paracetamol, asta fiind echivalentul a circa 0,6 miliarde de cutii a 20 de tablete;<\/p>\n<p>\n&#8211; in Romania se consuma circa 400 de milioane de doze, asta fiind echivalentul a circa 20 de milioane de cutii a 20 de tablete. Pretul este ridicol, 3-5 lei pe cutie. Nici o apa minerala la jumatate nu mai cumperi sub 5-6 lei.<\/p>\n<p>\n&nbsp;<\/p>\n<p>\nA\u015fadar. Paracetamol este prescurtarea de la para-acetilaminofenol, iar acetaminofen este prescurtarea de la N-acetil-p-aminofenol &#8211; o descriere a moleculei, ilustrate chiar sub titlu, vedeti gruparea acetil, gruparea amino, etc.<\/p>\n<p>\n&nbsp;<\/p>\n<p>\nDecreteii folosesc de cand se stiu Paracetamol, se chema Acetaminofen pe vremuri, ne amintim foliile acelea de plastic prin care se vedeau tabletele albe. Le fabrica Sicomed sau Antibiotice, nu mai tin exact minte, sigur cineva isi aminteste.<\/p>\n<p>\n&nbsp;<\/p>\n<p>\nDe unde s-a plecat in discutia cu paracetamolol?&nbsp; Probabil de la un studiu publicat in 2019 care a utilizat biomarkeri in sangele ombilical si a indicat asociere a prezentei acetaminofenului in sangele ombilical cu riscul crescut de ADHD si autism. <strong>Studiul a fost observational, cu insuficienta putere de a stabili sau desfiinta o cauzalitate. <\/strong><\/p>\n<p>\n&nbsp;<\/p>\n<p>\nSau, si mai probabil, mai recent, de la un studiu publicat in 14 august 2025, care a analizat rezultatele din 46 de studii despre legatura posibila intre utilizarea prenatala a paracetamolului si tulburarile dezvoltarii neuronale, inclusiv autismul si ADHD, are urmatoarele concluzii:<\/p>\n<p>\nDintre cele 46 de studii care au fost analizate, 27 au indicat o asociere semnificativa, 9 au arata absenta asocierii si 4 au indicat efect protector al paracetamolului.<\/p>\n<p>\n<strong>Analiza sustine o asociere intre expunerea prenatala la paracetamol si incidenta crescuta a tulburarilor de dezvoltare neuronala. O asociere posibil, nicidecum sigura si nicidecum o cauzalitate.<\/strong><\/p>\n<p>\n&nbsp;<\/p>\n<p>\nDar studiul cu cele mai relevante concluzii, cu design de calitate, a fost publicat in 2024. <strong>Lucrarea arata ca nu exista nici o asociere intre paracetamol administrat prenatal si riscul de ADHD, autism sau afectare cognitiva a copilului.<\/strong><\/p>\n<p>\n&nbsp;<\/p>\n<p>\nAstfel incat, utilizarea paracetamolului in sarcina \u2013 atunci cand nu exista alternativa terapeutica &#8211; este in continuare sustinuta de catre ghiduri si asociatii medicale \u2013 inclusiv, de exemplu, asociatia medicilor obstetricieni din SUA si societatea pentru medicina materno-fetala din SUA).<\/p>\n<p>\n&nbsp;<\/p>\n<p>\nLa sfarsit un avertisment de care multi nu mai tin seama. Nu paracetamolul sau orice alt medicament sunt periculoase, ci folosirea lor fara indicatia medicului sau a farmacistului. Astazi, in epoca digitala, in loc sa cerem indicatia medicului sau a farmacistului, il consultam pe Dr. Google, Conf. Dr. Yahoo si Prof. Dr. Artificial Intelligence. Iar asta nu este bine, nu este bine deloc.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nu scriu opinii ca si consilier al nimanui, tot ceea ce public este convingerea si responsabilitatea mea personala.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[61360,61362,558,61361,61359,22185,47404],"class_list":["post-240521","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-acetaminofen","tag-c8h9no2","tag-dragos-damian","tag-n-acetil-p-aminofenol","tag-paraacetil-aminofenol","tag-paracetamol","tag-terapia-cluj"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/240521","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=240521"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/240521\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=240521"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=240521"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=240521"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}