\nMuta\u0163iile KRAS sunt prezente \u00een aproape 25% din toate cazurile de cancer la om \u015fi apar frecvent \u00een unele dintre cele mai r\u0103sp\u00e2ndite tipuri de tumori. MYC este, de asemenea, considerat un gen critic asociat cancerului \u015fi este disfunc\u0163ional \u00een aproximativ 50-70% din cazurile de cancer.<\/p>\n
\nAceste gene au fost considerate \u201eincurabile” – medicii nu au reu\u015fit s\u0103 creeze medicamente eficiente \u00eempotriva lor, \u00een special \u00eempotriva MYC.<\/p>\n
\nNoua tehnologie folose\u015fte ARN interferent inversat (RNAi) – molecule mici care pot \u201e\u00eenchide” genele problematice. Diferen\u0163a e c\u0103 aceast\u0103 molecul\u0103 poate viza ambele gene simultan.<\/p>\n
\nRezultatele sunt impresionante: atacarea simultan\u0103 a ambelor gene a fost de 40 de ori mai eficient\u0103 la uciderea celulelor canceroase dec\u00e2t folosirea unei singure molecule \u00eempotriva unei singure gene.<\/p>\n
\n\u201e\u0162intirea simultan\u0103 a dou\u0103 gene cancerigene este similar\u0103 cu t\u0103ierea ambelor c\u0103lc\u00e2ie ale cancerului”, explic\u0103 Chad Pecot, autorul principal al studiului publicat \u00een Journal of Clinical Investigation.<\/p>\n
\nAceast\u0103 abordare ar putea trata un grup mult mai mare de pacien\u0163i dec\u00e2t tehnologiile anterioare. Cancerele pulmonare, colorectale \u015fi pancreatice – care \u00eempreun\u0103 reprezint\u0103 aproape jum\u0103tate de milion de cazuri noi anual \u00een SUA – ar putea fi \u0163intele principale.<\/p>\n
\nTehnologia e at\u00e2t de flexibil\u0103 \u00eenc\u00e2t cercet\u0103torii cred c\u0103 ar putea fi adaptat\u0103 pentru a viza oricare dou\u0103 gene de interes. Pecot sugereaz\u0103 c\u0103 ar putea fi posibil s\u0103 dezactiveze chiar trei \u0163inte simultan.<\/p>\n
\nStudiul se bazeaz\u0103 pe o descoperire similar\u0103 din iunie a aceleia\u015fi echipe, care dezvoltase o metod\u0103 pentru o variant\u0103 specific\u0103 KRAS.<\/p>\n","protected":false},"excerpt":{"rendered":"
O echip\u0103 de la Universitatea din Carolina de Nord a dezvoltat o tehnologie revolu\u0163ionar\u0103 care poate dezactiva simultan dou\u0103 dintre cele mai dificile \u0163inte ale cancerului – genele KRAS \u015fi MYC.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[14610,37921,204],"class_list":["post-239105","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-cancer","tag-gene","tag-tehnologie"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/239105","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=239105"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/239105\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=239105"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=239105"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=239105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}