\nDescoperirea a pornit de la o observa\u0163ie surprinz\u0103toare: pacien\u0163ii cu cancer de prostat\u0103 \u015fi diabet care luau medicamente ce vizeaz\u0103 proteina PPAR\u03b3 nu au prezentat recidive \u00een perioada urm\u0103ririi medicale, transmite Scitech Daily.<\/p>\n
\nStudiul retrospectiv a analizat 69 de pacien\u0163i cu cancer de prostat\u0103 \u015fi diabet de tip 2, urm\u0103ri\u0163i \u00eentre 2014-2023 de Universitatea Medical\u0103 din Innsbruck. Rezultatele au fost completate cu teste pe culturi celulare \u015fi experimente pe \u015foareci.<\/p>\n
\nPioglitazona nu doar c\u0103 a \u00eencetinit cre\u015fterea celulelor canceroase de prostat\u0103, dar le-a \u015fi modificat metabolismul, \u00eengreun\u00e2nd supravie\u0163uirea \u015fi r\u0103sp\u00e2ndirea acestora. Medicamentul pare s\u0103 reprogrameze celulele canceroase prin activarea receptorului PPAR\u03b3, o protein\u0103 cunoscut\u0103 pentru rolul s\u0103u \u00een reglarea metabolismului \u015fi sensibilit\u0103\u0163ii la insulin\u0103.<\/p>\n
\n\u201ePentru prima dat\u0103, avem observa\u0163ii clinice care arat\u0103 c\u0103 pacien\u0163ii cu cancer de prostat\u0103 \u015fi diabet zaharat care au primit medicamente care vizeaz\u0103 aceast\u0103 protein\u0103 au r\u0103mas f\u0103r\u0103 recidive”, explic\u0103 profesorul Lukas Kenner, unul dintre autorii principali.<\/p>\n
\nCercet\u0103torii avertizeaz\u0103 \u00eens\u0103 c\u0103 sunt necesare studii clinice suplimentare pentru a confirma dac\u0103 tratamentul poate fi utilizat \u015fi la pacien\u0163ii cu cancer de prostat\u0103 care nu sufer\u0103 de diabet.<\/p>\n","protected":false},"excerpt":{"rendered":"
Un medicament obi\u015fnuit pentru diabet, pioglitazona, s-ar putea dovedi o arm\u0103 nea\u015fteptat\u0103 \u00een lupta \u00eempotriva cancerului de prostat\u0103, arat\u0103 un studiu realizat de cercet\u0103tori de la Universitatea Ume\u00e5.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[56443,15493,32260],"class_list":["post-236811","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-cancer-de-prostata","tag-diabet","tag-medicament"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/236811","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=236811"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/236811\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=236811"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=236811"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=236811"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}