{"id":236079,"date":"2025-04-28T20:02:38","date_gmt":"2025-04-28T20:02:38","guid":{"rendered":"https:\/\/bm.dev.synology.me\/?p=236079"},"modified":"2025-04-28T20:02:38","modified_gmt":"2025-04-28T20:02:38","slug":"toxina-care-ar-putea-sta-la-baza-cresterii-ratei-de-cancer-intestinal-la-persoanele-sub-50-de-ani","status":"publish","type":"post","link":"https:\/\/bm.dev.synology.me\/?p=236079","title":{"rendered":"Toxina care ar putea sta la baza cre\u015fterii ratei de cancer intestinal la persoanele sub 50 de ani"},"content":{"rendered":"<p>\nCercet\u0103torii au descoperit c\u0103 anumite tulpini ale bacteriei E. coli produc o toxin\u0103 numit\u0103 colibactin\u0103, care ar putea fi par\u0163ial responsabil\u0103 pentru aceast\u0103 tendin\u0163\u0103 \u00eengrijor\u0103toare.<\/p>\n<p>\n\u00cen ultimele decenii, cazurile de cancer intestinal \u00een r\u00e2ndul persoanelor sub 50 de ani au crescut cu 22%, peste 2.600 de persoane din aceast\u0103 grup\u0103 de v\u00e2rst\u0103 fiind diagnosticate anual cu aceast\u0103 boal\u0103. Ceea ce este \u015fi mai \u00eengrijor\u0103tor este faptul c\u0103 multe dintre acestea nu prezint\u0103 factorii de risc tradi\u0163ionali, precum antecedente familiale, exces de greutate, fumat sau consum excesiv de alcool, scrie The Telegraph.<\/p>\n<p>\nStudiul publicat \u00een revista Nature arat\u0103 c\u0103 expunerea la colibactin\u0103 \u00een primii ani de via\u0163\u0103, p\u00e2n\u0103 la v\u00e2rsta de 10 ani, ar putea preg\u0103ti terenul pentru dezvoltarea cancerului intestinal mult mai t\u00e2rziu. Aceast\u0103 toxin\u0103 deterioreaz\u0103 ADN-ul celulelor intestinale prin introducerea de muta\u0163ii specifice.<\/p>\n<p>\nCercet\u0103torii de la Universitatea din California, San Diego, au analizat aproape 1.000 de genomi de cancer intestinal \u015fi au descoperit c\u0103 muta\u0163iile cauzate de colibactin\u0103 erau de 3,3 ori mai frecvente la pacien\u0163ii care au f\u0103cut cancer intestinal \u00eenainte de v\u00e2rsta de 40 de ani, comparativ cu cei care au dezvoltat boala dup\u0103 v\u00e2rsta de 70 de ani.<\/p>\n<p>\nDe\u015fi majoritatea tulpinilor de E. coli sunt inofensive \u015fi chiar benefice pentru sistemul nostru digestiv, tulpinile pks+ E. coli elibereaz\u0103 toxine care pot provoca cancer. \u00cen prezent, nu exist\u0103 metode accesibile pentru a determina dac\u0103 bacteriile din intestinul nostru produc aceste toxine d\u0103un\u0103toare.<\/p>\n<p>\nCercet\u0103torii nu \u015ftiu \u00eenc\u0103 exact cum sunt expu\u015fi copiii la bacteriile produc\u0103toare de colibactin\u0103, ceea ce face dificil\u0103 recomandarea unor m\u0103suri preventive specifice. Dr. Paul Brennan, de la Agen\u0163ia Interna\u0163ional\u0103 pentru Cercetarea Cancerului, afirm\u0103 c\u0103 se investigheaz\u0103 dac\u0103 expunerea are loc \u00een primele s\u0103pt\u0103m\u00e2ni de via\u0163\u0103 sau mai t\u00e2rziu prin surse alimentare.<\/p>\n<p>\nAlimentele contaminate \u015fi apa netratat\u0103 pot con\u0163ine aceste bacterii, astfel \u00eenc\u00e2t \u00eembun\u0103t\u0103\u0163irea siguran\u0163ei \u015fi igienei alimentare ar putea contribui la reducerea expunerii. De asemenea, unele bacterii produc\u0103toare de colibactin\u0103 sunt folosite \u00een probiotice \u015fi \u201esunt necesare mai multe cercet\u0103ri pentru a aborda siguran\u0163a acestui aspect&#8221;.<\/p>\n<p>\n\u00cen timp ce cercet\u0103torii fac teste pentru detectarea precoce a muta\u0163iilor asociate colibactinei, exist\u0103 numeroase m\u0103suri care pot reduce riscul de cancer intestinal:<\/p>\n<p>\n&#8211; ad\u0103ugarea de fibre \u00een diet\u0103 prin consumul de fructe, legume, leguminoase \u015fi cereale integrale<\/p>\n<p>\n&#8211; limitarea consumului de carne ro\u015fie \u015fi procesat\u0103<\/p>\n<p>\n&#8211; men\u0163inerea unei greut\u0103\u0163i s\u0103n\u0103toase<\/p>\n<p>\n&#8211; cre\u015fterea activit\u0103\u0163ii fizice<\/p>\n<p>\n&#8211; reducerea consumului de alcool.<\/p>\n<p>\nSophia Lowes, de la Cancer Research UK, subliniaz\u0103 importan\u0163a consult\u0103rii medicului \u00een cazul apari\u0163iei unor simptome neobi\u015fnuite: \u201eIndiferent de v\u00e2rsta pe care o ave\u0163i, dac\u0103 observa\u0163i ceva care nu este normal pentru dvs., nu ignora\u0163i acest lucru, consulta\u0163i medicul. \u00cen majoritatea cazurilor, nu va fi cancer, dar dac\u0103 este, depistarea timpurie poate face o diferen\u0163\u0103 real\u0103&#8221;.<\/p>\n<p>\nSimptomele cancerului intestinal includ modific\u0103ri ale scaunelor \u2013 cum ar fi scaune mai moi, diaree sau constipa\u0163ie \u2013 nevoia de a merge la toalet\u0103 mai des \u015fi s\u00e2nge \u00een scaun.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un studiu recent aduce \u00een prim-plan o posibil\u0103 explica\u0163ie pentru cre\u015fterea alarmant\u0103 a cazurilor de cancer intestinal \u00een r\u00e2ndul persoanelor tinere.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[60291,60292],"class_list":["post-236079","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-cancer-intestinal","tag-toxina"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/236079","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=236079"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/236079\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=236079"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=236079"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=236079"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}