\nGranulele pot fi declan\u015fate de diver\u015fi factori, precum muta\u0163ii genetice, inflama\u0163ii, expunerea la pesticide, viru\u015fi sau poluarea aerului.<\/p>\n
\n\u00cen mod normal, granulele de stres sunt temporare \u015fi dispar dup\u0103 ce celula \u00ee\u015fi revine. \u00cens\u0103 \u00een cazul bolii Alzheimer, ele persist\u0103 \u015fi devin cronice. Acest lucru provoac\u0103 un blocaj \u00een transportul molecular \u00eentre nucleul celulei \u015fi restul acesteia, perturb\u00e2nd produc\u0163ia de proteine esen\u0163iale \u015fi afect\u00e2nd activitatea a peste o mie de gene.<\/p>\n
\nDescoperirea ar putea explica de ce apar toate modific\u0103rile cunoscute ale bolii Alzheimer, inclusiv formarea pl\u0103cilor amiloide \u015fi a \u00eencurc\u0103turilor de proteine tau. Mai mult, cercet\u0103torii au observat c\u0103 aceste modific\u0103ri \u00eencep foarte devreme, \u00eenainte de apari\u0163ia semnelor vizibile ale bolii.<\/p>\n
\nPaolo Maria Rossini, \u015feful Departamentului de \u015ftiin\u0163e neurologice de la Irccs San Raffaele din Roma, prive\u015fte cu scepticism aceast\u0103 teorie. El sus\u0163ine c\u0103 boala Alzheimer este multifactorial\u0103 \u015fi c\u0103 beta-amiloidul, considerat p\u00e2n\u0103 acum principalul vinovat, nu este prezent \u00een toate formele de demen\u0163\u0103, potrivit La Repubblica.<\/p>\n
\n\u201eEste ca \u015fi cum ai spune c\u0103 un fulg de z\u0103pad\u0103 genereaz\u0103 o avalan\u015f\u0103”, explic\u0103 Rossini, suger\u00e2nd c\u0103 de\u015fi poate exista un punct de origine al bolii, acesta este at\u00e2t de mic \u015fi greu de detectat \u00eenc\u00e2t nu ajut\u0103 la diagnostic. El consider\u0103 c\u0103 tratamentul va necesita o combina\u0163ie de medicamente, nu o singur\u0103 solu\u0163ie.<\/p>\n
\nCercetarea se bazeaz\u0103 pe o analiz\u0103 sistematic\u0103 a studiilor existente \u015fi pe analize biomatematice ale bazelor de date, oferind pentru prima dat\u0103 un cadru unitar pentru \u00een\u0163elegerea acestei boli complexe.<\/p>\n","protected":false},"excerpt":{"rendered":"
O posibil\u0103 cauz\u0103 unic\u0103 pentru boala Alzheimer a fost dezv\u0103luit\u0103 de un studiu publicat \u00een revista Alzheimer’s & Dementia: apari\u0163ia granulelor de stres \u00een celulele nervoase. Acestea sunt grupuri de ARN \u015fi proteine care se formeaz\u0103 \u00een mod natural c\u00e2nd celulele sunt supuse unor factori de stres.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[36542,24812],"class_list":["post-233976","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-alzheimer","tag-cauza"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/233976","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=233976"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/233976\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=233976"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=233976"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=233976"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}