\nCercet\u0103torii de la Duke Human Vaccine Institute au reu\u015fit s\u0103 induc\u0103 formarea de anticorpi speciali, cunoscu\u0163i sub numele de anticorpi neutralizan\u0163i cu spectru larg sau bnAbs. Ace\u015fti anticorpi au capacitatea de a recunoa\u015fte \u015fi neutraliza numeroase tulpini de HIV, ceea ce ar putea deveni cheia unui viitor vaccin eficient.<\/p>\n
\nP\u00e2n\u0103 acum, generarea bnAbs la oameni a reprezentat o real\u0103 provocare pentru exper\u0163i. \u00cens\u0103 noul vaccin experimental, DHVI, a reu\u015fit aceast\u0103 performan\u0163\u0103 la mai mul\u0163i participan\u0163i, dup\u0103 administrarea a dou\u0103 doze, noteaz\u0103 ndtv.com.<\/p>\n
\nStudiul, publicat de jurnalul Cell, arat\u0103 c\u0103 este posibil s\u0103 se induc\u0103 bnAbs prin vaccinare, neutraliz\u00e2nd chiar \u015fi cele mai dificile tulpini de HIV, a declarat autorul principal, dr. Barton F. Haynes. \u201eEste un pas crucial, de\u015fi suntem \u00eenc\u0103 departe de a ob\u0163ine un vaccin finalizat”.<\/p>\n
\n\u00cen prima faz\u0103, au fost testa\u0163i 20 de participan\u0163i s\u0103n\u0103to\u015fi. Cincisprezece au primit dou\u0103 doze, iar cinci au primit trei doze. Vaccinul a ar\u0103tat r\u0103spunsuri imune puternice, cu o rat\u0103 de r\u0103spuns de 95% \u015fi o rat\u0103 de r\u0103spuns de 100% a celulelor T CD4+ dup\u0103 dou\u0103 doze. De asemenea, a indus anticorpi de neutralizare general\u0103.<\/p>\n
\nStudiul a fost \u00eentrerupt dup\u0103 ce un participant a avut o reac\u0163ie alergic\u0103 care nu i-a pus via\u0163a \u00een pericol, probabil din cauza unui aditiv.<\/p>\n","protected":false},"excerpt":{"rendered":"
Oamenii de \u015ftiin\u0163\u0103 au f\u0103cut un important pas \u00eenainte \u00een eforturile de a dezvolta un vaccin eficient \u00eempotriva HIV. Un studiu clinic de mici dimensiuni a testat un nou vaccin experimental denumit DHVI \u015fi rezultatele ini\u0163iale sunt \u00eencurajatoare.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[18747,14930],"class_list":["post-226982","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-hiv","tag-vaccin"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/226982","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=226982"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/226982\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=226982"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=226982"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=226982"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}