\nUn studiu recent a identificat o protein\u0103 numit\u0103 Cyclin Dependent Kinase 9 (Cdk9) ca fiind o \u0163int\u0103 promi\u0163\u0103toare pentru noi tratamente anticancerigene. Cdk9 joac\u0103 un rol crucial \u00een repararea ADN-ului deteriorat, o func\u0163ie esen\u0163ial\u0103 pentru suprimarea tumorilor.<\/p>\n
\nRolul proteinei a fost descoperit \u00een cadrul unor cercet\u0103ri efectuate \u00eentre Statele Unite \u015fi Italia, publicat\u0103 \u00een revista Oncogene \u015fi citat\u0103 de Il Messaggero.<\/p>\n
\nCdk9, cunoscut\u0103 \u015fi ca “noul gardian al genomului”, joac\u0103 un rol esen\u0163ial \u00een repararea ADN-ului deteriorat, \u00eempiedic\u00e2nd apari\u0163ia \u015fi proliferarea tumorilor.<\/p>\n
\nStudiul a demonstrat c\u0103 celulele canceroase lipsite de Cdk9 devin mai vulnerabile la chimioterapie.<\/p>\n
\nCercet\u0103torii consider\u0103 c\u0103 descoperirea lor poate duce la noi medicamente care vizeaz\u0103 Cdk9, fie ca monoterapie, fie \u00een combina\u0163ie cu alte tratamente.<\/p>\n
\nCdk9 monitorizeaz\u0103 genomul celulei pentru a preveni erorile \u00een secven\u0163a genetic\u0103. Lipsa Cdk9 afecteaz\u0103 negativ mecanismul de reparare a recombin\u0103rii omoloage, un proces vital pentru prevenirea muta\u0163iilor ADN.<\/p>\n
\nAlterarea Cdk9 \u00een tumori poate contribui la acumularea muta\u0163iilor care favorizeaz\u0103 cre\u015fterea \u015fi progresia cancerului.<\/p>\n
\nStudiul, publicat \u00een revista Oncogene, a demonstrat c\u0103 celulele canceroase lipsite de Cdk9 devin mai vulnerabile la chimioterapie.<\/p>\n
\nCercet\u0103torii consider\u0103 c\u0103 descoperirea lor poate duce la noi medicamente care vizeaz\u0103 Cdk9, fie ca monoterapie, fie \u00een combina\u0163ie cu alte tratamente.<\/p>\n
\n“Cdk9 este un nou gardian al genomului”, declar\u0103 Antonio Giordano, coordonatorul studiului.<\/p>\n
\n“Aceast\u0103 descoperire ne permite s\u0103 ad\u0103ug\u0103m o nou\u0103 pies\u0103 important\u0103 la \u00een\u0163elegerea noastr\u0103 privind modul \u00een care celulele \u00ee\u015fi aleg mecanismele de reparare”, adaug\u0103 Antonio Giordano.<\/p>\n","protected":false},"excerpt":{"rendered":"
Un studiu recent a identificat o protein\u0103 numit\u0103 Cyclin Dependent Kinase 9 (Cdk9) ca fiind o \u0163int\u0103 promi\u0163\u0103toare pentru noi tratamente anticancerigene. Cdk9 joac\u0103 un rol crucial \u00een repararea ADN-ului deteriorat, o func\u0163ie esen\u0163ial\u0103 pentru suprimarea tumorilor. Rolul proteinei a fost descoperit \u00een cadrul unor cercet\u0103ri efectuate \u00eentre Statele Unite \u015fi Italia, publicat\u0103 \u00een revista […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[14610,46854],"class_list":["post-224710","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-cancer","tag-proteina"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/224710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=224710"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/224710\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=224710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=224710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=224710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}