\nApar speran\u0163e dup\u0103 testarea unui vaccin terapeutic al companiei Moderna, care, combinat cu un alt medicament, pare s\u0103 protejeze \u00eempotriva recidivelor melanomului.<\/p>\n
\nUn candidat vaccin cu ARNm \u00eempotriva formelor de melanom cu risc ridicat, una dintre cele mai agresive forme de cancer de piele, continu\u0103 s\u0103 prezinte rezultate promi\u0163\u0103toare \u015fi ar putea fi supus unui proces accelerat de aprobare \u00eenc\u0103 din 2025.
\nVaccinul se nume\u015fte mRNA-4157\/V940 \u015fi exploateaz\u0103 aceea\u015fi tehnologie utilizat\u0103 pentru vaccinurile anti-Covid, dar este conceput \u00een a\u015fa fel \u00eenc\u00e2t sistemul imunitar s\u0103 genereze un r\u0103spuns \u00eempotriva unor cancere specifice.<\/p>\n
\nPoten\u0163ialul vaccin este un exemplu de medicin\u0103 personalizat\u0103, deoarece este conceput pornind de la genomul tumorii fiec\u0103rui pacient: sunt identificate muta\u0163ii specifice \u00eempotriva c\u0103rora trebuie antrenat sistemul imunitar, pentru a le codifica \u00een “re\u0163eta” ARNm a vaccinului.
\n\u00cen cadrul unui studiu clinic de faz\u0103 2, vaccinul a fost administrat \u00eempreun\u0103 cu un medicament imunoterapeutic dezvoltat de compania Merck (Keytruda) la 147 de pacien\u0163i \u00een urma extirp\u0103rii unui melanom \u00een stadiul 3 sau 4, forme deja avansate \u015fi cu risc ridicat de recidiv\u0103.
\nCombina\u0163ia de medicamente a redus cu 49% riscul de recidiv\u0103 a tumorii \u015fi de deces \u00een urm\u0103torii trei ani \u015fi a sc\u0103zut cu 62% riscul de r\u0103sp\u00e2ndire a celulelor tumorale.
\nDeocamdat\u0103, datele au fost comunicate doar de Moderna, dar nu au fost \u00eenc\u0103 publicate \u00eentr-o revist\u0103 \u015ftiin\u0163ific\u0103.<\/p>\n","protected":false},"excerpt":{"rendered":"
Apar speran\u0163e dup\u0103 testarea unui vaccin terapeutic al companiei Moderna, care, combinat cu un alt medicament, pare s\u0103 protejeze \u00eempotriva recidivelor melanomului. Un candidat vaccin cu ARNm \u00eempotriva formelor de melanom cu risc ridicat, una dintre cele mai agresive forme de cancer de piele, continu\u0103 s\u0103 prezinte rezultate promi\u0163\u0103toare \u015fi ar putea fi supus unui […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[8444,41769,14930],"class_list":["post-222517","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-avans","tag-cancer-de-piele","tag-vaccin"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/222517","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=222517"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/222517\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=222517"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=222517"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=222517"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}