{"id":214887,"date":"2023-04-10T10:38:10","date_gmt":"2023-04-10T10:38:10","guid":{"rendered":"https:\/\/bm.dev.synology.me\/?p=214887"},"modified":"2023-04-10T10:38:10","modified_gmt":"2023-04-10T10:38:10","slug":"proteina-care-ajuta-la-suprimarea-cresterii-tumorilor-studiu","status":"publish","type":"post","link":"https:\/\/bm.dev.synology.me\/?p=214887","title":{"rendered":"Proteina care ajut\u0103 la suprimarea cre\u015fterii tumorilor &#8211; studiu"},"content":{"rendered":"<p>\n<span style=\"font-size: 12px;\">Crearea unor medicamente eficiente \u015fi individualizate \u00eempotriva cancerului necesit\u0103 o \u00een\u0163elegere a modului \u00een care se dezvolt\u0103 cancerul.<\/span><\/p>\n<p>\n\u00centr-un studiu recent publicat \u00een Cell Reports, cercet\u0103torii de la University of Colorado Anschutz Medical Campus explic\u0103 descoperirea unei noi proteine implicate \u00eentr-un mecanism care suprim\u0103 diferite tipuri de tumori.<\/p>\n<p>\nDe mul\u0163i ani, oamenii de \u015ftiin\u0163\u0103 au \u00een\u0163eles c\u0103 anumite tipuri de muta\u0163ii genetice sunt la originea cancerului. Atunci c\u00e2nd func\u0163ioneaz\u0103 \u00een mod regulat, genele supresoare de tumori pot \u00eempiedica proliferarea necontrolat\u0103 a celulelor maligne \u015fi pot declan\u015fa procesul de apoptoz\u0103, un tip de moarte celular\u0103. Genele supresoare ale tumorii (gene protectoare) pot deveni disfunc\u0163ionale ca urmare a muta\u0163iilor, ceea ce ar putea favoriza cre\u015fterea cancerului, arat\u0103 studiul.<\/p>\n<p>Gena supresoare numit\u0103 TP53 \u201erestric\u0163ioneaz\u0103\u201d \u00een mod eficient dezvoltarea \u015fi cre\u015fterea multor tipuri diferite de tumori din corpul uman \u015fi este cea mai frecvent mutant\u0103 gen\u0103 supresoare de tumori \u00een cancerele umane. Aceast\u0103 gen\u0103 codific\u0103 o protein\u0103 numit\u0103 p53, care este at\u00e2t un inhibitor puternic al prolifer\u0103rii celulare, c\u00e2t \u015fi un inductor al apoptozei.<\/p>\n<p>\u201e\u00cen mai mult de jum\u0103tate din cazurile de cancer, TP53 nu este mutant\u0103, r\u0103m\u00e2n\u00e2nd \u00een schimb \u00eentr-o stare latent\u0103. \u00cen consecin\u0163\u0103, multe eforturi de cercetare au fost dedicate dezvolt\u0103rii de medicamente care ar putea reactiva aceast\u0103 form\u0103 latent\u0103 de p53 pentru terapia cancerului. Cu toate acestea, majoritatea cancerelor r\u0103spund la activarea p53 cu aceste medicamente printr-un blocaj tranzitoriu al prolifer\u0103rii celulare. Un r\u0103spuns mai bun la aceste medicamente ar fi eliminarea celulelor canceroase prin apoptoz\u0103. Prin urmare, este esen\u0163ial pentru noi s\u0103 \u00een\u0163elegem ce al\u0163i factori sunt necesari pentru o terapie eficient\u0103 \u00eempotriva cancerului care s\u0103 vizeze p53\u201d, explic\u0103 Zdenek Andrysik, Doctor, profesor asistent de cercetare \u00een domeniul Farmacologiei \u00een cadrul \u015ecolii de Medicin\u0103 a Universit\u0103\u0163ii din Colorado \u015fi unul dintre autorii lucr\u0103rii.<br \/>\n&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Crearea unor medicamente eficiente \u015fi individualizate \u00eempotriva cancerului necesit\u0103 o \u00een\u0163elegere a modului \u00een care se dezvolt\u0103 cancerul. \u00centr-un studiu recent publicat \u00een Cell Reports, cercet\u0103torii de la University of Colorado Anschutz Medical Campus explic\u0103 descoperirea unei noi proteine implicate \u00eentr-un mecanism care suprim\u0103 diferite tipuri de tumori. De mul\u0163i ani, oamenii de \u015ftiin\u0163\u0103 au [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[13243,246,7853],"class_list":["post-214887","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-ajutor","tag-crestere","tag-studiu"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/214887","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=214887"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/214887\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=214887"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=214887"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=214887"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}