{"id":210847,"date":"2022-12-07T12:48:46","date_gmt":"2022-12-07T12:48:46","guid":{"rendered":"https:\/\/bm.dev.synology.me\/?p=210847"},"modified":"2022-12-07T12:48:46","modified_gmt":"2022-12-07T12:48:46","slug":"studiu-de-ce-racim-mai-des-in-sezonul-rece-cercetatorii-au-aflat-motivul-si-ne-ofera-solutia-pentru-a-ne-proteja","status":"publish","type":"post","link":"https:\/\/bm.dev.synology.me\/?p=210847","title":{"rendered":"STUDIU De ce r\u0103cim mai des \u00een sezonul rece? Cercet\u0103torii au aflat motivul \u015fi ne ofer\u0103 solu\u0163ia pentru a ne proteja"},"content":{"rendered":"<p style=\"text-align: justify;\">\n<strong>\u201eEste pentru prima dat\u0103 c\u00e2nd avem o explica\u0163ie biologic\u0103, molecular\u0103 \u00een ceea ce prive\u015fte un factor al r\u0103spunsului nostru imunitar \u00eenn\u0103scut care pare s\u0103 fie limitat de temperaturile mai sc\u0103zute<\/strong>&#8220;, a declarat rinologul Dr. Zara Patel, profesor de otorinolaringologie \u015fi chirurgie a capului \u015fi g\u00e2tului la Stanford University School of Medicine din California. Ea nu a fost implicat\u0103 \u00een noul studiu.<\/p>\n<div style=\"text-align: justify;\">\n&nbsp;<\/div>\n<div style=\"text-align: justify;\">\nDe fapt, reducerea temperaturii din interiorul nasului cu doar 5 grade Celsius ucide aproape 50% din miliardele de celule care lupt\u0103 \u00eempotriva virusurilor \u015fi bacteriilor din n\u0103ri, potrivit studiului publicat mar\u0163i \u00een The Journal of Allergy and Clinical Immunology.<\/div>\n<div style=\"text-align: justify;\">\n&nbsp;<\/div>\n<div>\n<div style=\"text-align: justify;\">\n\u201e<strong>Aerul rece este asociat cu o cre\u015ftere a infec\u0163iilor virale, deoarece, \u00een esen\u0163\u0103, a\u0163i pierdut jum\u0103tate din imunitate doar prin acea mic\u0103 sc\u0103dere a temperaturii<\/strong>&#8220;, a declarat rinologul Dr. Benjamin Bleier, director al sec\u0163iei de otorinolaringologie de la Massachusetts Eye and Ear \u015fi profesor asociat la Harvard Medical School din Boston.<\/div>\n<div style=\"text-align: justify;\">\n&nbsp;<\/div>\n<div style=\"text-align: justify;\">\n<strong>\u201eEste important s\u0103 ne amintim c\u0103 acestea sunt studii in vitro, ceea ce \u00eenseamn\u0103 c\u0103, de\u015fi se folose\u015fte \u0163esut uman \u00een laborator pentru a studia acest r\u0103spuns imunitar, nu este un studiu care se desf\u0103\u015foar\u0103 \u00een interiorul nasului real al cuiva<\/strong>&#8220;, a declarat Patel \u00eentr-un e-mail. \u201e<strong>Adesea, concluziile studiilor in vitro sunt confirmate in vivo, dar nu \u00eentotdeauna&#8221;.<\/strong><\/div>\n<\/div>\n<p style=\"text-align: justify;\">\nPentru a \u00een\u0163elege de ce se \u00eent\u00e2mpl\u0103 acest lucru, Bleier \u015fi echipa sa \u015fi coautorul Mansoor Amiji, care conduce departamentul de \u015ftiin\u0163e farmaceutice de la Universitatea Northeastern din Boston, au pornit \u00eentr-o v\u00e2n\u0103toare de detectivi \u015ftiin\u0163ifici.<\/p>\n<h2 style=\"text-align: justify;\">\nExplica\u0163ia \u015ftiin\u0163ific\u0103<\/h2>\n<div style=\"text-align: justify;\">\nUn virus respirator sau o bacterie invadeaz\u0103 nasul, principalul punct de intrare \u00een organism. Imediat, partea din fa\u0163\u0103 a nasului detecteaz\u0103 germenul, cu mult \u00eenainte ca partea din spate a nasului s\u0103 fie con\u015ftient\u0103 de intrus, a descoperit echipa.<\/div>\n<div style=\"text-align: justify;\">\n&nbsp;<\/div>\n<div style=\"text-align: justify;\">\n\u00cen acel moment, celulele care c\u0103ptu\u015fesc nasul \u00eencep imediat s\u0103 creeze miliarde de copii simple ale lor \u00eensele, numite vezicule extracelulare, sau EV-uri.<\/div>\n<div style=\"text-align: justify;\">\n&nbsp;<\/div>\n<div style=\"text-align: justify;\">\n\u201e<strong>EV&#8217;s nu se pot diviza a\u015fa cum o pot face celulele, dar sunt ca ni\u015fte mici versiuni mini de celule special concepute pentru a merge \u015fi a ucide ace\u015fti viru\u015fi&#8221;<\/strong>, a spus Bleier. \u201e<strong>EV&#8217;s ac\u0163ioneaz\u0103 ca momeli, astfel \u00eenc\u00e2t acum, c\u00e2nd inhalezi un virus, acesta se lipe\u015fte de aceste momeli \u00een loc s\u0103 se lipeasc\u0103 de celule&#8221;.<\/strong><\/div>\n<div style=\"text-align: justify;\">\n&nbsp;<\/div>\n<div style=\"text-align: justify;\">\nAcele &#8220;Mini Me&#8217;s&#8221; sunt apoi expulzate de celule \u00een mucusul nazal, unde opresc germenii invadatori \u00eenainte ca ace\u015ftia s\u0103 ajung\u0103 la destina\u0163ie \u015fi s\u0103 se \u00eenmul\u0163easc\u0103, potrivit <a href=\"https:\/\/edition.cnn.com\/2022\/12\/06\/health\/why-winter-colds-flu-wellness\/index.html\">CNN<\/a>.<\/div>\n<div style=\"text-align: justify;\">\n&nbsp;<\/div>\n<div style=\"text-align: justify;\">\n\u201e<strong>Aceasta este una dintre, dac\u0103 nu chiar singura parte a sistemului imunitar care p\u0103r\u0103se\u015fte corpul pentru a merge s\u0103 lupte cu bacteriile \u015fi viru\u015fii \u00eenainte ca ace\u015ftia s\u0103 ajung\u0103 efectiv \u00een organism<\/strong>&#8220;, a spus Bleier.<\/div>\n<div style=\"text-align: justify;\">\n&nbsp;<\/div>\n<div style=\"text-align: justify;\">\nOdat\u0103 create \u015fi \u00eempr\u0103\u015ftiate \u00een secre\u0163iile nazale, miliardele de EV-uri \u00eencep apoi s\u0103 \u00eenghesuie germenii r\u0103pitori, a spus Bleier. \u201e<strong>Acesta este modul \u00een care organismul absoarbe ace\u015fti viru\u015fi inhala\u0163i, astfel \u00eenc\u00e2t s\u0103 nu poat\u0103 intra niciodat\u0103 \u00een celul\u0103 \u00een primul r\u00e2nd\u201d.<\/strong><\/div>\n<h2 style=\"text-align: justify;\">\nO cre\u015ftere mare a puterii imunitare<\/h2>\n<div style=\"text-align: justify;\">\nAtunci c\u00e2nd este atacat, nasul cre\u015fte produc\u0163ia de vezicule extracelulare cu 160%, a constatat studiul. Au existat diferen\u0163e suplimentare: EV-urile aveau mult mai mul\u0163i receptori pe suprafa\u0163a lor dec\u00e2t celulele originale, sporind astfel capacitatea de oprire a virusului a miliardelor de vezicule extracelulare din nas.<\/div>\n<div style=\"text-align: justify;\">\n&nbsp;<\/div>\n<div>\n<div style=\"text-align: justify;\">\nCelulele din organism con\u0163in, de asemenea, un uciga\u015f viral numit micro ARN, care atac\u0103 germenii invadatori. Cu toate acestea, EV-urile din nas con\u0163ineau de 13 ori mai multe secven\u0163e de micro ARN dec\u00e2t celulele normale, a constatat studiul.<\/div>\n<div style=\"text-align: justify;\">\n&nbsp;<\/div>\n<div style=\"text-align: justify;\">\nA\u015fadar, nasul vine la lupt\u0103 \u00eenarmat cu ni\u015fte superputeri suplimentare.<\/div>\n<h2 style=\"text-align: justify;\">\nDar ce se \u00eent\u00e2mpl\u0103 cu aceste avantaje atunci c\u00e2nd vine vremea rece?<\/h2>\n<div>\n<div style=\"text-align: justify;\">\nPentru a afla, Bleier \u015fi echipa sa au expus patru participan\u0163i la studiu la temperaturi de 4,4 grade Celsius, timp de 15 minute, iar apoi au m\u0103surat condi\u0163iile din interiorul cavit\u0103\u0163ilor lor nazale.<\/div>\n<div style=\"text-align: justify;\">\n&nbsp;<\/div>\n<div style=\"text-align: justify;\">\n\u201e<strong>Ceea ce am descoperit este c\u0103, atunci c\u00e2nd e\u015fti expus la aer rece, temperatura din nas poate sc\u0103dea cu p\u00e2n\u0103 la 5 grade Celsius. Iar acest lucru este suficient pentru a anula, \u00een esen\u0163\u0103, toate cele trei avantaje imunitare pe care le are nasul&#8221;,<\/strong> a spus Bleier.<\/div>\n<div style=\"text-align: justify;\">\n&nbsp;<\/div>\n<\/div>\n<\/div>\n<div style=\"text-align: justify;\">\nDe fapt, acel pic de r\u0103ceal\u0103 din v\u00e2rful nasului a fost suficient pentru a scoate din lupt\u0103 aproape 42% din veziculele extracelulare, a spus Bleier.<\/div>\n<div style=\"text-align: justify;\">\n&nbsp;<\/div>\n<div style=\"text-align: justify;\">\n<strong>\u201e\u00cen mod similar, ave\u0163i aproape jum\u0103tate din cantitatea acelor microARN-uri uciga\u015fe \u00een interiorul fiec\u0103rei vezicule \u015fi pute\u0163i avea o sc\u0103dere de p\u00e2n\u0103 la 70% a num\u0103rului de receptori de pe fiecare vezicul\u0103, ceea ce le face mult mai pu\u0163in lipicioase&#8221;,<\/strong> a spus el.<\/div>\n<div style=\"text-align: justify;\">\n&nbsp;<\/div>\n<div style=\"text-align: justify;\">\nCe efect are acest lucru asupra capacit\u0103\u0163ii dumneavoastr\u0103 de a lupta \u00eempotriva r\u0103celii, gripei \u015fi a Covid-19? Reduce la jum\u0103tate capacitatea sistemului imunitar de a lupta \u00eempotriva infec\u0163iilor respiratorii, a spus Bleier.<\/div>\n<h2 style=\"text-align: justify;\">\nCare este solu\u0163ia?<\/h2>\n<div>\n<div style=\"text-align: justify;\">\nPurtarea unei m\u0103\u015fti v\u0103 poate proteja de aerul rece care v\u0103 poate reduce imunitatea, spune un expert. \u201e<strong>Nu numai c\u0103 m\u0103\u015ftile v\u0103 protejeaz\u0103 de inhalarea direct\u0103 a viru\u015filor, dar este ca \u015fi cum a\u0163i purta un pulover pe nas&#8221;<\/strong>, a spus el.<\/div>\n<div style=\"text-align: justify;\">\n&nbsp;<\/div>\n<div style=\"text-align: justify;\">\nPatel a fost de acord: \u201e<strong>Cu c\u00e2t pute\u0163i men\u0163ine mai cald mediul intranazal, cu at\u00e2t mai bine va putea func\u0163iona acest mecanism de ap\u0103rare imunitar\u0103 \u00eenn\u0103scut\u0103. Poate \u00eenc\u0103 un motiv \u00een plus pentru a purta m\u0103\u015fti!&#8221;.<\/strong><\/div>\n<div style=\"text-align: justify;\">\n&nbsp;<\/div>\n<div style=\"text-align: justify;\">\n\u00cen viitor, Bleier se a\u015fteapt\u0103 s\u0103 vad\u0103 dezvoltarea unor medicamente nazale topice care s\u0103 se bazeze pe aceast\u0103 revela\u0163ie \u015ftiin\u0163ific\u0103. Aceste noi produse farmaceutice vor &#8220;\u00een esen\u0163\u0103, vor p\u0103c\u0103li nasul s\u0103 cread\u0103 c\u0103 tocmai a v\u0103zut un virus&#8221;, a spus el.<\/div>\n<div style=\"text-align: justify;\">\n&nbsp;<\/div>\n<div style=\"text-align: justify;\">\n&nbsp;<\/div>\n<\/div>\n<p>\n&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201eEste pentru prima dat\u0103 c\u00e2nd avem o explica\u0163ie biologic\u0103, molecular\u0103 \u00een ceea ce prive\u015fte un factor al r\u0103spunsului nostru imunitar \u00eenn\u0103scut care pare s\u0103 fie limitat de temperaturile mai sc\u0103zute&#8220;, a declarat rinologul Dr. Zara Patel, profesor de otorinolaringologie \u015fi chirurgie a capului \u015fi g\u00e2tului la Stanford University School of Medicine din California. Ea nu [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[23115,46303,53429,52738,7853,14898,11605],"class_list":["post-210847","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-celule","tag-nas","tag-racire-temperatura","tag-sezon-rece","tag-studiu","tag-temperaturi","tag-virus"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/210847","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=210847"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/210847\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=210847"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=210847"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=210847"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}