\nO molecul\u0103 descoperit\u0103 recent ar putea \u00eencetini sau stopa progresia maladiei Parkinson, potrivit unui studiu realizat de cercet\u0103tori de la Rutgers University \u015fi Scripps Research din SUA, potrivit medicalxpress.com.<\/p>\n
\nMaladia neurodegenerativ\u0103, care afecteaz\u0103 peste 10 milioane de persoane la nivel mondial, potrivit Parkinson’s Foundation, este incurabil\u0103. Parkinson este o tulburare a sistemului motor, iar cele patru simptome principale ale bolii, care apar lent \u00een timp, sunt tremurul, rigiditatea, instabilitatea postural\u0103, precum \u015fi tulbur\u0103rile de echilibru \u015fi coordonare.<\/p>\n
\n\u00cen cazul acestei maladii, proteina alfa-sinuclein\u0103 se acumuleaz\u0103 anormal \u00een celulele creierului, provoc\u00e2nd deteriorarea \u015fi moartea acestora. \u00cens\u0103, cercet\u0103torilor le-a fost foarte dificil s\u0103 \u0163inteasc\u0103 aceast\u0103 protein\u0103, pentru c\u0103 nu are o structur\u0103 fix\u0103 \u015fi \u00ee\u015fi modific\u0103 forma. Nivelurile mari de alfa-sinuclein\u0103 care se acumuleaz\u0103 \u00een creier accelereaz\u0103 procesul de deteriorare a celulelor, iar cercet\u0103torii \u00eencearc\u0103 s\u0103 g\u0103seasc\u0103 modalit\u0103\u0163i de a \u00eencetini producerea acestei proteine, ca form\u0103 de tratament.<\/p>\n
\n\u00cen 2014, expertul \u00een Parkinson M. Maral Mouradian, director al Rutgers Robert Wood Johnson Medical School Institute for Neurological Therapeutics, l-a contactat pe Matthew D. Disney, profesor de chimie la Scripps Research din Florida, pentru a explora o nou\u0103 idee de tratament pe baza unei tehnologii dezvoltate de cel de-al doilea.<\/p>\n
\nMetoda lui Disney implica plasarea pe structura ARN (acid ribonucleic) a unor mici molecule sau compu\u015fi similari medicamentelor. Cei doi colaboratori erau de p\u0103rere c\u0103 tehnologia inovatoare poate fi folosit\u0103 pentru a pune la punct un medicament care s\u0103 \u0163inteasc\u0103 ARN-ul mesager care codeaz\u0103 proteina, pentru a \u00eencetini producerea acesteia \u00een creierele pacien\u0163ilor cu Parkinson. Dac\u0103 proteina nu poate fi eliminat\u0103 cu ajutorul medicamentelor, ARN-ul poate reprezenta o \u0163int\u0103 viabil\u0103.<\/p>\n
\n\u00cen timpul cercet\u0103rilor lor, ace\u015ftia au descoperit un compus care previne acumularea proteinei \u00een creier. Noul compus, Synucleozid, reduce nivelurile de alfa-sinuclein\u0103 \u015fi protejeaz\u0103 celulele cerebrale de efectele toxice ale proteinelor pliate anormal, fapt care sugereaz\u0103 c\u0103 poate \u00eencetini progresia bolii.<\/p>\n
\nMouradian a spus c\u0103 acest tratament ar fi eficace \u00een cazul pacien\u0163ilor aflate \u00een primele stadii ale bolii, prezent\u00e2nd simptome minime.<\/p>\n
\n\u00cen prezent, sunt testate mai multe tratamente contra maladiei Parkinson, pe baz\u0103 de anticorpi, care, \u00eens\u0103, pot fi utile \u00een stadii t\u00e2rzii ale bolii, dup\u0103 ce deja s-au format acumul\u0103ri de alfa-sinuclein\u0103.<\/p>\n
\nMouradian a mai spus aceast\u0103 molecul\u0103 poate fi benefic\u0103 \u015fi \u00een cazul pacien\u0163ilor care sufer\u0103 de demen\u0163\u0103 cu corpi Lewy, boal\u0103 provocat\u0103 tot de acumularea de alfa-sinuclein\u0103.<\/p>\n
\nConceptul de \u0163intire a unor secven\u0163e din ARN pentru a reduce produc\u0163ia unor proteine poate fi util \u015fi \u00een cazul altor maladii neurodegenerative, precum Alzheimer.<\/p>\n
\nStudiul a fost publicat \u00een Proceedings of the National Academy of Sciences.<\/p>\n","protected":false},"excerpt":{"rendered":"
O molecul\u0103 descoperit\u0103 recent ar putea \u00eencetini sau stopa progresia maladiei Parkinson, potrivit unui studiu realizat de cercet\u0103tori de la Rutgers University \u015fi Scripps Research din SUA, potrivit medicalxpress.com. Maladia neurodegenerativ\u0103, care afecteaz\u0103 peste 10 milioane de persoane la nivel mondial, potrivit Parkinson’s Foundation, este incurabil\u0103. Parkinson este o tulburare a sistemului motor, iar cele […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[19913,10664,40820,9106],"class_list":["post-179494","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-descoperire","tag-incetinire","tag-maladie","tag-stopare"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/179494","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=179494"}],"version-history":[{"count":1,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/179494\/revisions"}],"predecessor-version":[{"id":179514,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/179494\/revisions\/179514"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=179494"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=179494"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=179494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}