\nEditas Medicine pl\u0103nuie\u015fte s\u0103 \u00eenceap\u0103 test\u0103rile pe oameni pentru a modifica ADN-UL \u015fi astfel ar putea vindeca orbirea infantil\u0103 mo\u015ftenit\u0103, potrivit The Telegraph.<\/p>\n
\nOamenii cu ADN-ul modificat genetic ar putea deveni o realitate \u00een urm\u0103torii doi ani dup\u0103 ce o companie biotech a anun\u0163at planurile de a \u00eencepe test\u0103rile unei tehnici inovatoare.<\/p>\n
\nEditas Medicine pl\u0103nuie\u015fte s\u0103 devin\u0103 primul laborator din lume care s\u0103 “editeze” ADN-ul pacien\u0163ilor care sufer\u0103 de o boal\u0103 genetic\u0103, \u00een cazul de fa\u0163\u0103 amauroza congenitala Leber, o orbire infantila mostenita, cauzata de o anomalie a unei singure gene. Oamenii de \u015ftiin\u0163\u0103 de la Editas cred c\u0103 pot repara aceast\u0103 anomalie prin intermediul tehnicii Crispr. Katrine Bosley, \u015feful executiv al Editas Medicine, a declarat \u00een timpul unei conferin\u0163e de pres\u0103 c\u0103 sper\u0103 ca firma s\u0103 \u00eenceap\u0103 testele pe pacien\u0163i orbi \u00een 2017.<\/p>\n
\nAr fi pentru prima dat\u0103 c\u00e2nd aceast\u0103 tehnic\u0103 ar fi folosit\u0103 pe oameni. \u00cen momentul de fa\u0163\u0103, editarea genetic\u0103 este interzis\u0103 \u00een Statele Unite, a\u015fa c\u0103 Editas Medicine ar avea nevoie de permisiune special\u0103 pentru teste.<\/p>\n
\nAceast\u0103 nou\u0103 tehnic\u0103 este \u00eemprumutat\u0103 de la bacterii. Bacteriile au \u00een ADN-ul lor o serie de cod genetic ce apar\u0163ine viru\u015filor, astfel bacteriile pot recunoa\u015fte momentul c\u00e2nd viru\u015fii se aproprie. C\u00e2nd bacteriile detecteaz\u0103 viru\u015fii, acestea elimin\u0103 o enzim\u0103 care atac\u0103 viru\u015fii. Oamenii de \u015ftiin\u0163\u0103 se folosesc de acest mecanism pentru a \u00eendep\u0103rta zonele mutate din ADN.<\/p>\n
\nPotrivit MIT Technology Review, pacien\u0163iilor Editas o s\u0103 le fie injectate \u00een ochii “supe de viru\u015fi”, complexului de enzime CRISPR\/Cas9, care duce la formarea de noi leg\u0103turi \u015fi la desfacerea altora, \u00een cadrul ADN-ului, \u00een anumite regiuni cromozomiale. Enzimele pot fi programate s\u0103 \u0163inteasc\u0103 o anumit\u0103 gen\u0103 problematic\u0103, ce este astfel \u00eenlocuit\u0103 sau reparat\u0103 cu ajutorul unei alte molecule, introdus\u0103 simultan cu enzimele.<\/p>\n
\nDac\u0103 tratamentul este un succes, aceea\u015fi tehnic\u0103 ar putea fi folosit pentru oamenii care sufer\u0103 de alte boli genetice precum boala Huntingon. <\/p>\n
\nTot anul aceasta, cercet\u0103torii chinezi au modificat, \u00een premier\u0103 mondial\u0103, genomul unor embrioni umani. Potrivit articolului din Protein & Cell, savan\u0163ii chinezi condu\u015fi de Junjiu Huang, cercet\u0103tor \u00een domeniul genetic la Universitatea Sun Yat-sen din Guangzhou, au \u00eencercat s\u0103 previn\u0103 \u00eengrijor\u0103rile de ordin etic utiliz\u00e2nd embrioni “non-viabili”, care nu pot duce la na\u015fterea unei persoane. Embrionii au fost ob\u0163inu\u0163i de la clinici chineze de fertilitate. Savan\u0163ii au \u00eencercat s\u0103 modifice gena responsabil\u0103 pentru talasemie (\u03b2-thalassaemia), o maladie a s\u00e2ngelui, poten\u0163ial mortal\u0103, folosind o tehnic\u0103 de modificare genetic\u0103 numit\u0103 CRISPR\/Cas9. Oamenii de \u015ftiin\u0163\u0103 au spus c\u0103 rezultatele au indicat prezen\u0163a unor obstacole majore \u00een calea utiliz\u0103rii metodei \u00een aplica\u0163ii medicale.<\/p>\n","protected":false},"excerpt":{"rendered":"
Editas Medicine pl\u0103nuie\u015fte s\u0103 \u00eenceap\u0103 test\u0103rile pe oameni pentru a modifica ADN-UL \u015fi astfel ar putea vindeca orbirea infantil\u0103 mo\u015ftenit\u0103, potrivit The Telegraph. Oamenii cu ADN-ul modificat genetic ar putea deveni o realitate \u00een urm\u0103torii doi ani dup\u0103 ce o companie biotech a anun\u0163at planurile de a \u00eencepe test\u0103rile unei tehnici inovatoare. Editas Medicine pl\u0103nuie\u015fte […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[6070,16199,36777,14023,30159,104,272,30102,32766,42053,37921,14357,274,10884,22465,8326,19136,6266,408,8018,8864,32558,9356,9440],"class_list":["post-129400","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-adn","tag-anunt","tag-bacterii","tag-boala","tag-caz","tag-chinezi","tag-companie","tag-fata","tag-folosire","tag-gena","tag-gene","tag-genetica","tag-incepere","tag-incercare","tag-laborator","tag-modificare","tag-mostenire","tag-oameni","tag-pacienti","tag-planuri","tag-stiinta","tag-suferinta","tag-teste","tag-virusi"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/129400","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=129400"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/129400\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=129400"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=129400"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=129400"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}