{"id":126555,"date":"2015-09-04T16:30:03","date_gmt":"2015-09-04T16:30:03","guid":{"rendered":"https:\/\/bm.dev.synology.me\/?p=126555"},"modified":"2015-09-04T16:30:03","modified_gmt":"2015-09-04T16:30:03","slug":"studiu-aspirina-ar-putea-stimula-imunoterapia-anticancer","status":"publish","type":"post","link":"https:\/\/bm.dev.synology.me\/?p=126555","title":{"rendered":"STUDIU: Aspirina ar putea stimula imunoterapia anticancer"},"content":{"rendered":"<p>\n<strong>Imunoterapia are poten\u0163ialul de a revolu\u0163iona tratamentele anticancer, oferind pacien\u0163ilor o reac\u0163ie autoimunitar\u0103 mai bun\u0103 \u015fi mai \u00eendelungat\u0103, cu mai pu\u0163ine efecte adverse dec\u00e2t tratamentele conven\u0163ionale, \u00eens\u0103 noile medicamente nu genereaz\u0103 \u00een toate cazurile acelea\u015fi efecte pozitive.<\/strong><\/p>\n<p>\nUnul dintre motive const\u0103 \u00een faptul c\u0103 tumorile canceroase produc cantit\u0103\u0163i mari dintr-o molecul\u0103, prostaglandin E2 (PGE2), care opre\u015fte reac\u0163ia normal\u0103 a sistemului imunitar, ce vizeaz\u0103 atacarea celulelor tumorale, potrivit cercet\u0103torilor de la Francis Crick Institute din Londra, autorii acestui studiu.<\/p>\n<p>\nAspirina blocheaz\u0103 produc\u0163ia de PGE2, iar savan\u0163ii britanici au descoperit c\u0103, atunci c\u00e2nd este administrat\u0103 \u00een combina\u0163ie cu un medicament folosit \u00een cadrul imunoterapiei, denumit anti-PD-1, se ob\u0163ine o \u00eencetinire substan\u0163ial\u0103 a cre\u015fterii cancerului intestinal \u015fi a melanomului, \u00een cazul \u015foarecilor, \u00een compara\u0163ie cu tratamentele ce constau doar \u00een imunoterapie.<\/p>\n<p>\n<strong>Oamenii de \u015ftiin\u0163\u0103 de\u0163in deja c\u00e2teva dovezi \u00een leg\u0103tur\u0103 cu faptul c\u0103 rezultatele ob\u0163inute \u00een studiul realizat pe \u015foareci vor fi valabile \u015fi \u00een cadrul testelor pe \u0163esuturi umane, \u00eens\u0103 medicii britanici spun c\u0103 vor avea nevoie de o perioad\u0103 destul de \u00eendelungat\u0103 \u00eenainte de a putea s\u0103 demonstreze acest lucru, dincolo de orice dubiu.<\/strong><\/p>\n<p>\nCu toate acestea, noua cercetare a contribuit la \u00eent\u0103rirea reputa\u0163iei de &#8220;medicament-minune&#8221; pe care o are aspirina. Sintetizat\u0103 pentru prima dat\u0103 de un chimist al companiei Bayer \u00een urm\u0103 cu peste un secol, aspirina este deja folosit\u0103 pentru prevenirea infarctului \u015fi, potrivit unor rapoarte preliminare, pentru a reduce riscul de dezvoltare a cancerului intestinal \u015fi a altor tipuri de cancer.<\/p>\n<p>\nCompaniile farmaceutice Merck \u015fi Bristol-Myers Squibb au aprobat recent medicamentele din clasa anti-PD-1, iar un medicament concurent, anti-PD-L1, este \u00een prezent \u00een stadiu de dezvoltare \u00een laboratoarele unor companii rivale, precum Roche \u015fi AstraZeneca.<\/p>\n<p>\n<strong>Studiul cercet\u0103t\u0103rilor britanici a fost publicat, joi, \u00een revista Cell.<\/strong><\/p>\n<p>\n<a name=\"13747195!\"><\/a><\/p>\n<p>\n<a name=\"12840865!\"><\/a><\/p>\n<p>\n<a name=\"12782216!\"><\/a><\/p>\n<p>\n<a name=\"11501079!\"><\/a><\/p>\n<p>\n<a name=\"10257128!\"><\/a><\/p>\n<p>\n&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Administrarea de aspirin\u0103 pacien\u0163ilor diagnostica\u0163i cu cancer ar putea cre\u015fte eficien\u0163a noilor medicamente &#8211; de obicei scumpe &#8211; care ajut\u0103 sistemul imunitar s\u0103 lupte \u00eempotriva tumorilor, au ar\u0103tat o serie de experimente realizate recent pe \u015foareci, informeaz\u0103 Reuters.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[41529,14610,41530],"class_list":["post-126555","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-aspirina","tag-cancer","tag-imunoterapie"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/126555","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=126555"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/126555\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=126555"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=126555"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=126555"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}