{"id":125232,"date":"2015-08-02T13:29:39","date_gmt":"2015-08-02T13:29:39","guid":{"rendered":"https:\/\/bm.dev.synology.me\/?p=125232"},"modified":"2015-08-02T13:29:39","modified_gmt":"2015-08-02T13:29:39","slug":"studiu-un-medicament-anticancer-poate-identifica-rezervoarele-secrete-de-hiv-din-organism","status":"publish","type":"post","link":"https:\/\/bm.dev.synology.me\/?p=125232","title":{"rendered":"STUDIU: Un medicament anticancer poate identifica &#8220;rezervoarele&#8221; secrete de HIV din organism"},"content":{"rendered":"<p>\n<strong>Potrivit unui studiu publicat \u00een PLoS Pathogens, medicamentul este &#8220;foarte puternic&#8221; \u00een ceea ce prive\u015fte reactivarea virusului ascuns. Cercet\u0103torii spun c\u0103 descoperirile din cadrul acestui studiu sunt importante, dar trebuie s\u0103 se evalueze eventualele efecte adverse asupra pacien\u0163ilor.<\/strong><\/p>\n<p>\nPuterea &#8220;rezervoarelor&#8221; ascunse de HIV a fost demonstrat\u0103 \u00een celebru caz al bebelu\u015fului din Mississippi.<\/p>\n<p>\n\u00cen urm\u0103 cu doi ani, o feti\u0163\u0103 american\u0103 &#8211; cunoscut\u0103 sub denumirea &#8220;bebelu\u015ful din Mississippi&#8221; &#8211; a p\u0103rut c\u0103 s-a vindecat de HIV. \u00cens\u0103 remisiunea ei a durat doar pu\u0163in peste doi ani, dup\u0103 stoparea tratamentului.<\/p>\n<p>\nUn alt caz spectaculos a fost prezentat \u00een iulie, la o conferin\u0163\u0103 organizat\u0103 de International AIDS Society (IAS), \u00een ora\u015ful canadian Vancouver. O t\u00e2n\u0103r\u0103 fran\u0163uzoaic\u0103 \u00een v\u00e2rst\u0103 de 18 ani, diagnosticat\u0103 cu HIV \u00een copil\u0103rie, a intrat \u00een remisiune, \u00een ciuda faptului c\u0103 nu a mai luat \u00een ultimii 12 ani medicamente \u00eempotriva acestui virus periculos care declan\u015feaz\u0103 SIDA. Acesta este primul caz \u00eenregistrat pe plan mondial ce vizeaz\u0103 intrarea \u00eentr-o remisiune \u00eendelungat\u0103 a unui copil infectat cu HIV.<\/p>\n<p style=\"text-align: center;\">\n<img decoding=\"async\" alt=\"\" src=\"http:\/\/storage0.dms.mpinteractiv.ro\/media\/401\/341\/5531\/14660805\/2\/farmacie-shutterstock.jpg?height=454&#038;width=604\" style=\"width: 604px; height: 454px; margin: 2px;\" \/><\/p>\n<p>\n<strong>Exper\u0163ii \u00een domeniu consider\u0103 c\u0103 oamenii de \u015ftiin\u0163\u0103 trebuie s\u0103 ini\u0163ieze o serie de studii suplimentare pentru a \u00een\u0163elege motivul pentru care anumi\u0163i pacien\u0163i pot s\u0103 controleze virusul dup\u0103 oprirea tratamentului.<\/strong><\/p>\n<p>\nT\u00e2n\u0103ra s-a n\u0103scut \u00een 1996 \u015fi a primit virusul de la mama ei &#8211; fie \u00een ultimul semestru al sarcinii, fie la na\u015ftere. La v\u00e2rsta de trei luni, medicii i-au administrat patru medicamente antiretrovirale. \u00cens\u0103 familia ei a decis s\u0103 stopeze tratamentul atunci c\u00e2nd feti\u0163a avea v\u00e2rsta de aproape \u015fase ani.<\/p>\n<p>\nDup\u0103 12 ani, concentra\u0163iile virale din fluxul ei sangvin sunt \u00een continuare prea mici pentru a putea fi m\u0103surate, de\u015fi medicii au avertizat-o c\u0103 aceast\u0103 situa\u0163ie ar putea s\u0103 se schimbe.<\/p>\n<p>\n<strong>Recent, oamenii de \u015ftiin\u0163\u0103 au reu\u015fit s\u0103 alunge virusul care declan\u015feaz\u0103 SIDA din celulele \u00een care acesta se refugiaz\u0103, la pacien\u0163ii trata\u0163i cu antiretrovirale, \u015fi consider\u0103 c\u0103 aceast\u0103 strategie &#8211; numit\u0103 &#8220;kick and kill&#8221; (love\u015fte \u015fi ucide) &#8211; s-ar putea dovedi util\u0103 \u00een lunga \u015fi dificila misiune de creare a unui medicament capabil s\u0103 elimine HIV definitiv.<\/strong><\/p>\n<p>\n\u00cen ceea ce prive\u015fte medicamentul anticancer cu poten\u0163ial de a fi utilizat \u00een aceast\u0103 strategie, echipa de medici de la UC Davis School of Medicine, SUA, a analizat PEP005 &#8211; unul dintre ingredientele dintr-o terapie folosit\u0103 \u00een prevenirea cancerului la pacien\u0163ii a c\u0103ror piele a fost afectat\u0103 de soare.<\/p>\n<p>\nMedicamentul a fost testat pe celule cultivate \u00een laborator, precum \u015fi pe mostre prelevate de la 13 pacien\u0163i cu HIV. <strong>\u00cen urma experimentelor, s-a demonstrat c\u0103 PEP005 are capacitatea de a reactiva HIV aflat \u00een stare latent\u0103 \u015fi poate reprezenta un punct de pornire pentru noi tratamente contra acestui virus.<\/strong><\/p>\n<p>\n<a name=\"14621261!\"><\/a><\/p>\n<p>\n<a name=\"14541499!\"><\/a><\/p>\n<p>\n&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un medicament anticancer s-a dovedit a fi eficient \u00een identificarea \u00een organism a &#8220;rezervoarelor&#8221; secrete de HIV, virusul care provoac\u0103 SIDA, \u00een cazul pacien\u0163ilor care par a fi \u00een remisiune dup\u0103 ce au urmat o terapie antiretroviral\u0103, informeaz\u0103 bbc.com<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[41254,18747,32260],"class_list":["post-125232","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-anticancer","tag-hiv","tag-medicament"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/125232","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=125232"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/125232\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=125232"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=125232"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=125232"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}