dailymail.co.uk<\/a>.<\/p>\n\n“Dac\u0103 modific\u0103rile epigenetice sunt transmise de la tat\u0103 la copil, ar trebui s\u0103 putem s\u0103 le detect\u0103m \u00een sperm\u0103”, a ad\u0103ugat profesorul Daniele Fallin, un alt cercet\u0103tor implicat \u00een acel studiu.<\/p>\n
\nStudiul a analizat factorii epigenetici din ADN-ul extras din sperma unui num\u0103r de 44 de b\u0103rba\u0163i.<\/p>\n
\nVoluntarii f\u0103ceau parte dintr-un studiu mai vast care \u00eencearc\u0103 s\u0103 determine factorii ce influen\u0163eaz\u0103 evolu\u0163ia copiilor \u00een stadii timpurii, \u00eenainte ca ace\u015ftia s\u0103 fie diagnostica\u0163i cu autism.<\/p>\n
\nStudiul a inclus \u015fi mame \u00eens\u0103rcinate care aveau deja cel pu\u0163in un copil diagnosticat cu autism \u015fi a colectat informa\u0163ii \u015fi probe biologice de la acele femei, de la ta\u0163ii bebelu\u015filor lor \u015fi de la copiii \u00een\u015fi\u015fi, dup\u0103 na\u015ftere.<\/p>\n
\nLa \u00eenceputul sarcinii, probe de sperm\u0103 au fost recoltate de la ta\u0163ii inclu\u015fi \u00een acest studiu.<\/p>\n
\nLa un an dup\u0103 na\u015fterea bebelu\u015filor, ace\u015ftia au fost analiza\u0163i \u00een vederea detect\u0103rii unor semne timpurii de autism cu ajutorul metodei Autism Observation Scale for Infants (AOSI).<\/p>\n
\nCercet\u0103torii americani au extras apoi ADN din fiecare prob\u0103 de sperm\u0103 \u015fi au c\u0103utat factorii epigenetici \u00een 45.000 de pozi\u0163ii diferite din structura genomului acelor voluntari.<\/p>\n
\nApoi, ei au comparat probabilitatea ca un factor epigenetic s\u0103 se afle \u00eentr-o anumit\u0103 pozi\u0163ie din structura genomului cu scorurile AOSI ob\u0163inute de fiecare copil.<\/p>\n
\nSavan\u0163ii au descoperit astfel 193 de locuri diferite pentru care prezen\u0163a sau absen\u0163a factorilor epigenetici era asociat\u0103 din punct de vedere statistic cu scorurile AOSI.<\/p>\n
\nAnaliz\u00e2nd genele aflate \u00een apropierea acelor locuri, cercet\u0103torii au descoperit c\u0103 multe dintre ele erau \u00eenrudite cu genele implicate \u00een procesele de dezvoltare, \u00een special cu procesul de dezvoltare neurologic\u0103.<\/p>\n
\nPatru dintre cele 10 pozi\u0163ii genomiale care prezint\u0103 cea mai puternic\u0103 asociere cu scorurile AOSI se aflau \u00een apropierea genelor asociate cu sindromul Prader-Willi, o maladie genetic\u0103 ale c\u0103rei simptome comportamentale exist\u0103 \u015fi \u00een cazul autismului.<\/p>\n
\nMai mul\u0163i dintre factorii epigenetici deficitari au fost de asemenea descoperi\u0163i \u00een creierele indivizilor diagnostica\u0163i cu autism.<\/p>\n
\n\u00cen prezent, pe pia\u0163\u0103 nu este disponibil niciun test genetic sau epigenetic care s\u0103 fie capabil s\u0103 cuantifice riscul de autism.<\/p>\n
\nStudiul a fost publicat \u00een revista International Journal of Epidemiology.<\/p>\n","protected":false},"excerpt":{"rendered":"
Originea autismului la copii s-ar putea afla \u00een sperma ta\u0163ilor acestora, potrivit unui studiu care a descoperit o anumit\u0103 asociere \u00eentre ADN-ul din lichidul seminal \u015fi un tipar distinct de factori care ar putea s\u0103 declan\u015feze aceast\u0103 maladie, informeaz\u0103 dailymail.co.uk.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[33251,22790],"class_list":["post-120669","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-autism","tag-sperma"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/120669","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=120669"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/120669\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=120669"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=120669"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=120669"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}