{"id":116921,"date":"2015-01-22T17:57:16","date_gmt":"2015-01-22T17:57:16","guid":{"rendered":"https:\/\/bm.dev.synology.me\/?p=116921"},"modified":"2015-01-22T17:57:16","modified_gmt":"2015-01-22T17:57:16","slug":"studiu-cercetatorii-au-creat-un-firewall-genetic-pentru-noi-forme-de-viata","status":"publish","type":"post","link":"https:\/\/bm.dev.synology.me\/?p=116921","title":{"rendered":"STUDIU: Cercet\u0103torii au creat un &#8220;firewall genetic&#8221; pentru noi forme de via\u0163\u0103"},"content":{"rendered":"<p>\nReu\u015fita a dou\u0103 echipe diferite de cercet\u0103tori, considerat\u0103 o piatr\u0103 de hotar \u00een domeniul &#8220;biologiei sintetice&#8221;, vine la un an dup\u0103 ce savan\u0163ii au creat organisme care folosesc un cod genetic diferit de oricare altul prezent \u00een formele de via\u0163\u0103 cunoscute.<\/p>\n<p>\n<strong>Descoperirea, publicat\u0103 miercuri \u00een revista Nature, ofer\u0103 ceea ce un cercet\u0103tor a numit &#8220;firewall genetic&#8221;, adic\u0103 o metod\u0103 de izolare biologic\u0103 a unui organism modificat genetic, \u00eentr-un mediu anume, care este singurul ce \u00eei permite acelei forme de via\u0163\u0103 s\u0103 tr\u0103iasc\u0103.<\/strong><\/p>\n<p>\nDe\u015fi dou\u0103 laboratoare au reu\u015fit aceast\u0103 performan\u0163\u0103 \u00een cazul bacteriilor, &#8220;nu exist\u0103 nicio barier\u0103 fundamental\u0103&#8221; de aplicare a acestei tehnici \u00een cazul plantelor \u015fi animalelor, potrivit biologului George Church, de la Harvard Medical School, care a condus una dintre echipe. &#8220;Cred c\u0103 ne mi\u015fc\u0103m \u00een acea direc\u0163ie&#8221;, a spus Church.<\/p>\n<p>\n<strong>Dac\u0103 noua biotehnologie va fi una de succes, va putea fi folosit\u0103 asupra unor microorganisme modificate, pentru utiliz\u0103ri de la cele mai banale p\u00e2n\u0103 la unele exotice, cum ar fi producerea de iaurt \u015fi br\u00e2nzeturi, sintetizarea de substan\u0163e industriale \u015fi biocombustibili, cur\u0103\u0163area de\u015feurilor toxice \u015fi producerea de medicamente.<\/strong><\/p>\n<p>\nMicrobii sunt deja utiliza\u0163i pentru astfel de aplica\u0163ii. \u00cen unele cazuri, ace\u015ftia con\u0163in gene provenite de la un organism ne\u00eenrudit, transform\u00e2ndu-i \u00een &#8220;organisme modificate genetic&#8221;, cu scopul, de exemplu, de a se hr\u0103ni cu petrol sau derivate ale acestuia, \u00een cazul unor accidente ecologice, sau de a produce insulin\u0103. Utilizarea pe scar\u0103 larg\u0103 a OMG a fost \u00eens\u0103 restric\u0163ionat\u0103 din cauza temerilor c\u0103 ar putea s\u0103 se r\u0103sp\u00e2ndeasc\u0103 \u00een natur\u0103 \u015fi s\u0103 afecteze negativ mediul.<\/p>\n<p>\n\u00cen 2013, echipa de cercet\u0103tori condus\u0103 de George Church a anun\u0163at c\u0103 a reu\u015fit s\u0103 treac\u0103 dincolo de ingineria genetic\u0103, cre\u00e2nd organisme &#8220;recodificate din punct de vedere al genomului&#8221;. Aceast\u0103 recodificare \u00eenseamn\u0103 c\u0103 o anume por\u0163iune din ADN-ul organismului ofer\u0103 instruc\u0163iunile pentru producerea unui aminoacid (compus chimic de baz\u0103 pentru proteine) diferit de cei produ\u015fi de instruc\u0163iunile oferite de aceea\u015fi por\u0163iune de ADN \u00een cazul tuturor celorlalte organisme vii. Cercet\u0103torii au rescris gramatica genetic\u0103, comenteaz\u0103 Reuters.<\/p>\n<p>\n\u00cen cadrul noilor studii, echipele conduse de Church \u015fi un fost coleg al s\u0103u, Farren Isaacs, au creat tulpini de bacterii din specia E. coli care con\u0163in ADN pentru producerea unui aminoacid produs de om \u015fi au nevoie de aminoacizi sintetici pentru a supravie\u0163ui.<\/p>\n<p>\nPentru c\u0103 ace\u015fti aminoacizi nu exist\u0103 \u00een natur\u0103, potrivit lui Isaacs, care lucreaz\u0103 la Universitatea Yale, &#8220;firewall-ul&#8221; rezultat \u00eenseamn\u0103 c\u0103 orice OMG care ar putea s\u0103 ias\u0103 din mediul controlat al unui laborator, fabric\u0103 sau c\u00e2mp agricol ar muri.<\/p>\n<p>\nEchipa condus\u0103 de George Church a adus 49 de modific\u0103ri genetice bacteriilor E. coli pentru a le face dependente de aminoacidul sintetic. \u015eansele ca un microorganism &#8220;s\u0103 desfac\u0103&#8221; toate aceste schimb\u0103ri sunt extrem de mari, potrivit calculelor cercet\u0103torului britanic. Prin cuplarea recodific\u0103rii genomului cu acest &#8220;firewall&#8221;, biologii ar putea crea microbi care nu vor putea s\u0103 scape \u00een natur\u0103 \u015fi care, prin \u00eencorporarea de noi aminoacizi, ar putea produce noi tipuri de medicamente \u015fi polimeri, conform declara\u0163iilor lui George Church.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cercet\u0103torii au creat o bacterie care poate supravie\u0163ui doar \u00een prezen\u0163a unei substan\u0163e chimice create de om, dep\u0103\u015find un obstacol major \u00een domeniul utiliz\u0103rii extinse a organismelor modificate genetic (OMG).<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[510],"tags":[14357,39317,7853],"class_list":["post-116921","post","type-post","status-publish","format-standard","hentry","category-actualitate","tag-genetica","tag-organisme-modificate-genetic","tag-studiu"],"_links":{"self":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/116921","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=116921"}],"version-history":[{"count":0,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=\/wp\/v2\/posts\/116921\/revisions"}],"wp:attachment":[{"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=116921"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=116921"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bm.dev.synology.me\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=116921"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}